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Regulatory T cells and innate immune regulation in tumor immunity

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An Erratum to this article was published on 10 August 2006

An Erratum to this article was published on 10 August 2006

Abstract

Innate and adaptive immunity play important roles in immunosurveillance and tumor destruction. However, increasing evidence suggests that tumor-infiltrating immune cells may have a dual function: inhibiting or promoting tumor growth and progression. Although regulatory T (Treg) cells induce immune tolerance by suppressing host immune responses against self- or nonself-antigens, thus playing critical roles in preventing autoimmune diseases, they might inhibit antitumor immunity and promote tumor growth. Recent studies demonstrate that elevated proportions of Treg cells are present in various types of cancers and suppress antitumor immunity. Furthermore, tumor-specific Treg cells can inhibit immune responses only when they are exposed to antigens presented by tumor cells. Therefore, Treg cells at tumor sites have detrimental effects on immunotherapy directed to cancer. This review will discuss recent progress in innate immunity, Treg cells, and their regulation through Toll-like receptor (TLR) signaling. It was generally thought that TLR-mediated recognition of specific structures of invading pathogens initiate innate and adaptive immune responses through dendritic cells. New evidence suggests that TLR signaling may directly regulate the suppressive function of Treg cells. Linking TLR signaling to the functional control of Treg cells opens intriguing opportunities to manipulate TLR signaling to control both innate and adaptive immunity against cancer.

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Acknowledgements

This work is in part supported by grants from China NSF 30025039, National Institutes of Health (R01 CA90327, R01 CA101795, P01 CA94237, P50 CA58204, P50 CA93459), American Cancer Society, and Cancer Research Institute.

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  1. Cancer Institute, Second Affiliated Hospital, Zhejiang University Medical School, Hangzhou, People’s Republic of China

    Rong-Fu Wang

  2. Center for Cell and Gene Therapy, Baylor College of Medicine, ALKEK Building, N1120, Houston, TX, 77030, USA

    Rong-Fu Wang

  3. Department of Pathology, Baylor College of Medicine, ALKEK Building, N1120, Houston, TX, 77030, USA

    Rong-Fu Wang

  4. Department of Immunology, Baylor College of Medicine, ALKEK Building, N1120, Houston, TX, 77030, USA

    Rong-Fu Wang

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An erratum to this article can be found at http://dx.doi.org/10.1007/s00281-006-0044-1

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Wang, RF. Regulatory T cells and innate immune regulation in tumor immunity. Springer Semin Immun 28, 17–23 (2006). https://doi.org/10.1007/s00281-006-0022-7

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