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Human innate B cells: a link between host defense and autoimmunity?

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Abstract

B cells play a variety of immunoregulatory roles through their antigen-presentation ability and through cytokine and chemokine production. Innate immune activation of B cells may play a beneficial role through the generation of natural cross-reactive antibodies, by maintaining B cell memory and by exercising immunomodulatory functions that may provide protection against autoimmunity. In this article, we review human B cell populations and their functional properties, with a particular focus on a population of inherently autoreactive B cells, which seem to play an important physiological role in innate immunity, but which, if selected into adaptive immune responses, appear to become pathogenic agents in systemic lupus erythematosus.

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Acknowledgements

This work was supported in part by grants to J.A. (NIAMS K08AR048303 and the Lupus Foundation of America) and I.S. (RO1 AI049660-01A1 and U19 AI56390).

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  1. Department of Medicine, Clinical Immunology and Rheumatology Unit, University of Rochester Medical School, 601 Elmwood Avenue, Box 695, Rochester, NY 14642, USA

    Eric C. B. Milner, Jennifer Anolik, Amedeo Cappione & Iñaki Sanz

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  1. Eric C. B. Milner
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  2. Jennifer Anolik
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  4. Iñaki Sanz
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Correspondence to Iñaki Sanz.

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Milner, E.C.B., Anolik, J., Cappione, A. et al. Human innate B cells: a link between host defense and autoimmunity?. Springer Semin Immun 26, 433–452 (2005). https://doi.org/10.1007/s00281-004-0188-9

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  • DOI: https://doi.org/10.1007/s00281-004-0188-9

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