Abstract
A total of 26 patients with advanced colorectal cancer received 60 mg/m2 methotrexate i. v. on days 1 – 4; 400 mg/m2 5-fluorouracil i. v. on days 2, 3, 5, and 6; and 100 mg/m2 6S-leucovorin i. v. on days 2, 3, 5, and 6. Interferon-α2b at a dose of 3 million U was given i. m. daily for the 6 days of chemotherapy. Courses were repeated every 3 weeks. There were four partial responses for a response rate of 15% (95% confidence interval 2 – 28%). In all, 14 patients expressed grade 3 toxicity; 9 patients had diarrhea, 3 had stomatitis, and 2 developed leukopenia. In conclusion, multimodal biochemical modulation of 5-fluorouracil, at least on this schedule, does not seem to be effective, as it results in severe toxicity.
Similar content being viewed by others
Author information
Authors and Affiliations
Additional information
Received: 5 November 1995 / Accepted: 17 January 1996
Rights and permissions
About this article
Cite this article
Cascinu, S., Alessandroni, P., Rossi, D. et al. Multimodal biochemical modulation of 5-fluorouracil by leucovorin, methotrexate, and interferon alpha in patients with advanced colorectal cancer. Cancer Chemother Pharmacol 38, 385–386 (1996). https://doi.org/10.1007/s002800050499
Issue Date:
DOI: https://doi.org/10.1007/s002800050499