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H2-receptor antagonist influences dasatinib pharmacokinetics in a patient with Philadelphia-positive acute lymphoblastic leukemia

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Abstract

We recently reported in this journal that administration of acid suppressant such as an H2-receptor antagonist (H2RA) and a proton pump inhibitor can decrease the absorption of dasatinib from the gastrointestinal tract, thereby resulting in a significant decrease in its plasma concentration. Here, we report a patient treated with dasatinib and H2RA famotidine for whom the total area under the total plasma concentration–time curve (AUC0–12) of dasatinib dramatically increased after cessation of famotidine from 505.7 to 1,816.3 ng·h/mL. This is the first report to confirm the drug interaction between dasatinib and H2RA by using sequential pharmacokinetic profiling.

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References

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Authors and Affiliations

  1. Department of Hematology, Kagawa Prefectural Central Hospital, Takamatsu, Japan

    Akihito Matsuoka & Kimihiro Kawakami

  2. Department of Hematology, Oncology, Nephrology, and Rheumatology, Akita University School of Medicine, 1-1-1 Hondo, Akita City, Akita, 010-8543, Japan

    Naoto Takahashi & Kenichi Sawada

  3. Department of Pharmacy, Akita University Hospital, Akita City, Japan

    Masatomo Miura & Takenori Niioka

  4. Division of Hematology, Department of Internal Medicine, Faculty of Medicine, Kagawa University, Kagawa, Japan

    Akihito Matsuoka & Takuya Matsunaga

Authors
  1. Akihito Matsuoka
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  2. Naoto Takahashi
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  3. Masatomo Miura
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  4. Takenori Niioka
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  5. Kimihiro Kawakami
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  6. Takuya Matsunaga
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  7. Kenichi Sawada
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Corresponding author

Correspondence to Naoto Takahashi.

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Matsuoka, A., Takahashi, N., Miura, M. et al. H2-receptor antagonist influences dasatinib pharmacokinetics in a patient with Philadelphia-positive acute lymphoblastic leukemia. Cancer Chemother Pharmacol 70, 351–352 (2012). https://doi.org/10.1007/s00280-012-1900-4

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  • DOI: https://doi.org/10.1007/s00280-012-1900-4

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