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Chemoprotection and enhancement of cancer chemotherapeutic efficacy of cyclophosphamide in mice bearing Ehrlich ascites carcinoma by diphenylmethyl selenocyanate

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Abstract

Purpose

Chemoprotective effect of diphenylmethyl selenocyanate against cyclophosphamide (CP) induced cellular toxicity and antitumor efficacy was evaluated in mice bearing Ehrlich ascites carcinoma.

Methods

Diphenylmethyl selenocyanate (3 mg/kg.b.w.) was administered orally and CP was given intraperitoneally (25 mg/kg.b.w). The effects were observed on the level of lipid peroxidation, antioxidant enzymes status, serum transaminase (ALT, AST) activity, hematological profile, transplantable murine tumor growth, apoptosis induction in tumor cells, and life span of tumor bearing hosts.

Results

The selenium compound restored the levels of antioxidant enzymes system, decreased the level of lipid peroxidation and serum transaminase activity. Hematological profile reverted to near normal level after selenium compound treatment. Treatment with the selenium compound also resulted in significant tumor growth regression along with significant upregulation of apoptosis, increased in mean survival time and life span of tumor bearing host.

Conclusions

Results clearly indicate that diphenylmethyl selenocyanate has the potential to reduce the cellular toxicity of CP at the same time improving its antitumor efficacy.

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Acknowledgments

The authors wish to thank the Dr. Jaydip Biswas, Director, Chittaranjan National Cancer Institute, India for support in this study.

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Authors and Affiliations

  1. Department of Cancer Chemoprevention, Chittaranjan National Cancer Institute, 37, S. P. Mukherjee Road, Kolkata, 700026, West Bengal, India

    Pramita Chakraborty, Ugir Hossain Sk & Sudin Bhattacharya

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  1. Pramita Chakraborty
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  2. Ugir Hossain Sk
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  3. Sudin Bhattacharya
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Correspondence to Sudin Bhattacharya.

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Chakraborty, P., Sk, U.H. & Bhattacharya, S. Chemoprotection and enhancement of cancer chemotherapeutic efficacy of cyclophosphamide in mice bearing Ehrlich ascites carcinoma by diphenylmethyl selenocyanate. Cancer Chemother Pharmacol 64, 971–980 (2009). https://doi.org/10.1007/s00280-009-0950-8

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