References
Slamon DJ, Leyland-Jones B, Shak S et al (2001) Use of chemotherapy plus a monoclonal antibody against HER 2 for metastatic breast cancer that overexpresses HER 2. N Engl J Med 344:783–792
Stemmler HJ, Schmitt M, Willems A et al (2007) Ratio of trastuzumab in serum and cerebrospinal fluid is altered in HER2-positive breast cancer patients with brain metastases and impairment of blood-brain barrier. Anti-Cancer Drug 18:23–28
Geyer CE, Forster J, Lindquist D et al (2006) Lapatinib plus capecitabine for HER-2 positive advanced breast cancer. N Engl J Med 355:2733–2743
Clayton AJ, Danson S, Jolly S et al (2004) Incidence of cerebral metastases in patients treated with trastuzumab for metastatic breast cancer. Br J Cancer 91:639–643
Gori S, Rimondini S, De Angelis V et al (2007) Central nervous system metastases in HER2 positive metastatic breast cancer patients treated with trastuzumab: incidence, survival, and risk factors. The Oncologist 12:766–773
Bendell JC, Domcheck SM, Burstein HJ et al (2003) Central nervous system metastases in women who receive trastuzumab-based therapy for metastatic breast carcinoma. Cancer 97:2972–2977
Lai R, Dang CT, Malkin MG, Abrey LE (2004) The risk of central nervous system metastases after trastuzumab therapy in patients with breast carcinoma. Cancer 101:810–816
Shmueli E, Wigler N, Inbar M (2004) Central nervous system progression among patients with metastatic breast cancer responding to trastuzumab treatment. Eur J Cancer 40:379–382
Metro G, Sperduti I, Russillo M et al (2007) Clinical utility of continuing trastuzumab beyond brain progression in HER-2 positive metastatic breast cancer. Oncologist 12:1467–1469
Gori S, De Angelis V, Colozza M et al (2007) In reply. Oncologist 12:1469–1471
Grossi PM, Ochiai H, Archer GE et al (2003) Efficacy of intracerebral microinfusion of trastuzumab in an athymic rat model of intracerebral metastatic breast cancer. Clin Cancer Res 9:5514–5520
Laufman LR, Forsthoefel KF (2001) Use of intrathecal trastuzumab in a patient with carcinomatous meningitis. Clin Breast Cancer 2:235
Stemmler HJ, Schmitt M, Harbeck N et al (2006) Application of intrathecal trastuzumab (Herceptin trade mark) for treatment of meningeal carcinomatosis in HER 2 overexpressing metastatic breast cancer. Oncol Rep 15:1373–1377
Platini C, Long J, Walter S (2006) Meningeal carcinomatosis from breast cancer treated with intrathecal trastuzumab. Lancet Oncol 7:778–780
Stemmler HJ, Mengele K, Schmitt M et al (2008) Intrathecal trastuzumab (herceptin) and methotrexate for meningeal carcinomatosis in HER2 overexpressing metastatic breast cancer: a case report. Anticancer Drug 19:832–836
Fouladi M, Chintagumpala M, Laningham FH et al (2006) White matter lesions detected by magnetic resonance imaging after radiotherapy in children with medulloblastoma or primitive neuroectodermal tumor. J Clin Oncol 22:4551–4560
Gori S, Sidoni A, Colozza M et al (2007) EGFR, MAPK, and Akt status by immunohisochemistry (IHC) are not correlated with clinical outcome in HER-2 positive (HER2 +) metastatic breast cancer (MBC) patients (pts) treated with trastuzumab (T) with or without chemotherapy (CT). J Clin Oncol Suppl 25:54s (abstract 1090)
Nahta R, Yu D, Hung M-C et al (2006) Mechanisms of disease: understanding resistance to HER2-targeted therapy in human breast cancer. Nat Clin Pract Oncol 3:269–280
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Colozza, M., Minenza, E., Gori, S. et al. Extended survival of a HER-2-positive metastatic breast cancer patient with brain metastases also treated with intrathecal trastuzumab. Cancer Chemother Pharmacol 63, 1157–1159 (2009). https://doi.org/10.1007/s00280-008-0859-7
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DOI: https://doi.org/10.1007/s00280-008-0859-7