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Administration of oxaliplatin to a pregnant woman with rectal cancer

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Abstract

Purpose

The platinum agent oxaliplatin could be useful in treatment of cancer in pregnant women, but it is fetotoxic in rats and its effect on the human fetus is unknown.

Methods

Oxaliplatin was administered to a 25-year-old pregnant woman with metastatic rectal cancer from 20 to 30 weeks gestational age as part of the mFOLFOX-6 regimen.

Results

The patient gave birth to a healthy girl at 33 weeks gestational age. At follow-up, the 3-year-old child had achieved all appropriate growth and developmental milestones.

Discussion

Oxaliplatin is a component of several modern chemotherapy regimens. This report demonstrates the administration of oxaliplatin in the second and third trimesters of pregnancy without apparent fetal harm.

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Authors and Affiliations

  1. Vanderbilt University School of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA

    Michael Gensheimer

  2. Department of Medicine, Division of Hematology-Oncology, Vanderbilt University Medical Center, Nashville, TN, USA

    Catherine A. Jones & A. Craig Lockhart

  3. Department of Obstetrics and Gynecology, Vanderbilt University Medical Center, Nashville, TN, USA

    Cornelia R. Graves

  4. Department of Surgery, Vanderbilt University Medical Center, Nashville, TN, USA

    Nipun B. Merchant

  5. Vanderbilt-Ingram Cancer Center, 777 Preston Research Building, Nashville, TN, 37232-6302, USA

    A. Craig Lockhart

Authors
  1. Michael Gensheimer
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  2. Catherine A. Jones
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  3. Cornelia R. Graves
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  4. Nipun B. Merchant
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  5. A. Craig Lockhart
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Corresponding author

Correspondence to A. Craig Lockhart.

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Gensheimer, M., Jones, C.A., Graves, C.R. et al. Administration of oxaliplatin to a pregnant woman with rectal cancer. Cancer Chemother Pharmacol 63, 371–373 (2009). https://doi.org/10.1007/s00280-008-0731-9

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  • DOI: https://doi.org/10.1007/s00280-008-0731-9

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