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The rise of reticulated platelets after intensive chemotherapy for AML reduces the need for platelet transfusions

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Abstract

 We assumed that a recovery of thrombopoiesis after intensive chemotherapy for acute myelogenous leukemia (AML) could reduce the need for prophylactic platelet transfusions. We therefore assessed the start of platelet production by means of daily determination of reticulated platelets (RP). The increase in RP occurred on day 20 (median) after the start of chemotherapy and was followed by a rise of peripheral platelet counts 2–3 days thereafter. Consequently, a rise of RP during the period of recovery can be regarded as representing the reconstitution of the peripheral platelet count and may reduce or eliminate the need for prophylactic platelet transfusions.

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Authors and Affiliations

  1. Clinic of Blood Group Serology and Transfusion Medicine, Vienna University Hospital School of Medicine, Währinger Gürtel 18–20, A-1090 Vienna, Austria Tel.: 0043-1-40400/5315, Fax: 0043-1-40400/5321, , , , , , AT

    P. Stohlawetz, G. Stiegler, P. Höcker & S. Panzer

  2. Clinic of Internal Medicine I, Department of Haematology, Vienna University Hospital School of Medicine, Vienna, Austria, , , , , , AT

    P. Knöbl

Authors
  1. P. Stohlawetz
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  2. G. Stiegler
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  3. P. Höcker
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  4. S. Panzer
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  5. P. Knöbl
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Received: December 10, 1998 / Accepted: March 3, 1999

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Stohlawetz, P., Stiegler, G., Höcker, P. et al. The rise of reticulated platelets after intensive chemotherapy for AML reduces the need for platelet transfusions. Ann Hematol 78, 271–273 (1999). https://doi.org/10.1007/s002770050513

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  • DOI: https://doi.org/10.1007/s002770050513

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