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Acute myeloid leukemia M2 and t(8;21)(q22;q22) with an unusual phenotype: myeloperoxidase (+), CD13 (–), CD14 (–), and CD33 (–)

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Abstract

 Cases of myeloid surface antigen-negative acute myeloid leukemia (AML) are rare. We describe the morphological, cytochemical, immunologic, and cytogenetic features of two patients with AML with maturation (FAB M2) and the phenotype MPO+, CD13 (–), CD33(–), CD56(+). Cytogenetic studies demonstrated t(8;21)(q22;q22). These findings suggest an association between the lack of CD13 and CD33 in myeloperoxidase-positive AML and the presence of t(8;21).

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Authors and Affiliations

  1. Department of Hematology, Hospital Universitario de Getafe, Getafe, Madrid 28905, Spain Tel.: 0034-1-6839360 e-mail: javela@ran.es, jagarciavela@aehh.org, , , , , , ES

    J. A. García Vela, I. Delgado, L. García Alonso, M. C. Monteserin, L. Benito, N. Somolinos & F. Oña

  2. Department of Cytogenetics, Hospital 12 de Octubre, Universidad Complutense, Madrid, Spain, , , , , , ES

    M. Martin

Authors
  1. J. A. García Vela
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  2. M. Martin
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  3. I. Delgado
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  4. L. García Alonso
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  5. M. C. Monteserin
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  6. L. Benito
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  7. N. Somolinos
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  8. F. Oña
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Received: August 8, 1998 / Accepted: January 27, 1999

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García Vela, J., Martin, M., Delgado, I. et al. Acute myeloid leukemia M2 and t(8;21)(q22;q22) with an unusual phenotype: myeloperoxidase (+), CD13 (–), CD14 (–), and CD33 (–). Ann Hematol 78, 237–240 (1999). https://doi.org/10.1007/s002770050508

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  • DOI: https://doi.org/10.1007/s002770050508

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