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BCL6 rearrangement in a patient with mantle cell lymphoma

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Abstract

 We describe a patient with mantle cell lymphoma (MCL) associated with BCL6 gene rearrangement. MCL is a distinct subtype of non-Hodgkin's lymphoma characterized by CD5+, CD10–, CD20+, t(11;14)(q13;q32) and PRAD1/cyclin D1 overexpression. Although rearrangement of the BCL6 gene is the most frequent genetic change among diffuse lymphomas and some follicular lymphomas this is the first report of a patient with MCL associated with BCL6 rearrangement.

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Authors and Affiliations

  1. Third Department of Internal Medicine, Akita University School of Medicine, 1–1–1 Hondo, Akita 010, Japan, , , , , , JP

    I. Miura, A. Ohshima, A. Chubachi, T. Nimura, A. Komatsuda, S. Utsumi, M. Saito, T. Machii, S. Nakamura, M. Seto & A. B. Miura

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  1. I. Miura
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  2. A. Ohshima
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  3. A. Chubachi
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  4. T. Nimura
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  5. A. Komatsuda
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  6. S. Utsumi
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  7. M. Saito
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  8. T. Machii
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  9. S. Nakamura
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  10. M. Seto
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  11. A. B. Miura
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Additional information

Received: 6 January 1997 / Accepted: 17 February 1997

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Miura, I., Ohshima, A., Chubachi, A. et al. BCL6 rearrangement in a patient with mantle cell lymphoma. Ann Hematol 74, 247–250 (1997). https://doi.org/10.1007/s002770050293

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  • DOI: https://doi.org/10.1007/s002770050293

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