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Therapy of childhood acute myelogenous leukemias

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Abstract

Acute myelogenous leukemia (AML) accounts for approximately 20% of acute leukemias in children. Although AML is more resistant to chemotherapy than acute lymphoblastic leukemia (ALL), significant progress in improving outcome for AML patients has been achieved over the past 15 years. This can be attributed to intensification of chemotherapy, increased use of bone marrow transplantation, and improved supportive care. Thus 30–50% of children with AML achieve long-term event-free survival with current treatment strategies [61, 66, 85, 96]. This review gives an overview about the evolution of and rationale for current pediatric treatment protocols, with special emphasis on the German Berlin-Frankfurt-Münster (BFM) studies, and discusses new directions for the future.

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Authors and Affiliations

  1. Department of Pediatric Hematology/Oncology, University of Münster, Albert-Schweitzer-Strasse 33, D-48149 Münster, Germany, , , , , , DE

    J. Vormoor, J. Boos, H. Jürgens, J. Ritter & U. Creutzig

  2. Department of Pediatrics, University of Ulm, Prittwitzstrasse 43, D-89070 Ulm, Germany, , , , , , DE

    K. Stahnke

Authors
  1. J. Vormoor
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  2. J. Boos
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  3. K. Stahnke
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  4. H. Jürgens
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  5. J. Ritter
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  6. U. Creutzig
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Additional information

Received: 26 January 1996 / Accepted: 2 April 1996

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Vormoor, J., Boos, J., Stahnke, K. et al. Therapy of childhood acute myelogenous leukemias. Ann Hematol 73, 11–24 (1996). https://doi.org/10.1007/s002770050193

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  • DOI: https://doi.org/10.1007/s002770050193

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