Abstract
Plasma cell tumors (plasmacytomas-PCT) of the bone, or extramedullary PCT, may be diagnosed in patients with or without the diagnostic criteria for systemic multiple myeloma (MM). The reason for the local development of these tumors is not clear. Recent reports emphasize the contribution of CT and MRI in the detection of bone lesions and their expansion into the soft tissues. We report the development of PCT in nine patients with MM under maintenance treatment with α-IFN, of whom six had no evidence of systemic relapse and three had indications of early relapse. The PCT were located in the pelvis (4), thoracic (3), cervical (1), and lumbar (2) spine and in 8/9 cases were not demonstrable on plain X-rays. These observations suggest that frequent screening with advanced imaging techniques may detect local disease expansion in asymptomatic patients. Early application of radiochemotherapy may improve prognosis.
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References
Barlogie B, Epstein J, Selvanayagam P, Alexanian R (1989) Plasma cell myeloma — new biological insights and advances in therapy. Blood 73: 865–879
Caligaris-Cappio F, Bergui L, Gregoretti MG, Gaidano G, Gaboli K, Schena M, Zallone A, Marchisio P (1991) Role of bone marrow stromal cells in the growth of human multiple myeloma. Blood 77: 2688–2693
Durie B (1982) Staging and kinetics of multiple myeloma. Clin Haematol 11: 3–18
Grander D, von Stedingk LV, von Stedingk M, Wasserman J, Einhorn S (1991) Influence of interferon on antibody production and viability of malignant cells from patients with multiple myeloma. Eur J Haemtol 46: 17–25
Kyle R, Schreiman J, McLeod R, Beabout J (1985) Computed tomography in diagnosis and management of multiple myeloma and its variants. Arch Intern Med 145: 1451–1452
Ludwig H, Tsolacoff D, Neyhold A, Fruhwald F, Rasoul S, Fritz E (1987) Magnetic resonance imaging of the spine in multiple myeloma. Lancet II: 364–366
Mandelli F, Tribalto M, Avvisati G, Cantonetti M, Petrucci MT, Boccadoro M, Pilery A, Marmont F, Resengotti L, Lauta V, Dammacco F (1988) Recombinant interferon alpha-2b (Intron A) as postinduction therapy for responding multiple myeloma patients. M84 protocol. Cancer Treat Rev 15 [Suppl A]: 43–48
Moulopoulos L, Granfield C, Dimopoulos M, Kim E, Alexian R, Libshitz H(1993) Extraosseous multiple myeloma: imaging features. Am J Radiol 161: 1083–1087
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Vaiopoulos, G., Viniou, N., Plata, E. et al. Development of plasma cell tumors during treatment of multiple myeloma. Ann Hematol 72, 317–320 (1996). https://doi.org/10.1007/s002770050178
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DOI: https://doi.org/10.1007/s002770050178