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Complete haematological and cytogenetic response to interferon alpha-2a of a myeloproliferative disorder with eosinophilia associated with a unique t(4;7) aberration

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Abstract

 A female patient with eosinophilia and cardiac symptoms was found to have a unique chromosomal aberration [t(4;7)(q11;p13)] of bone-marrow precursors. The disorder was classified as a chronic myeloproliferative syndrome with eosinophilia. Due to a significant increase in the white blood cell and eosinophil count during initial treatment with prednisone and hydroxyurea, Interferon alpha-2a was administered at a dose of 3–5×106 I.U. s.c., five times per week, and induced a long-term complete haematological and cytogenetic response. The clinical features of this case are presented and discussed in the context of the current literature.

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Authors and Affiliations

  1. Department of Haematology/Oncology, Hannover Medical School, Carl-Neuberg-Strasse 1, 30625 Hannover, Germany e-mail: Schoeffski.Patrick@MH-Hannover.de Tel.: +49-511-5324077 Fax: +49-511-5324077, , , , , , DE

    P. Schöffski, A. Ganser & B. Hertenstein

  2. Gemeinschaftspraxis für Laboratoriumsmedizin Dr. Eberhardt et al., Brauhausstrasse 4, 44137 Dortmund, Germany, , , , , , DE

    U. Pascheberg

  3. Institut für Pathologie, Medizinische Hochschule Hannover, Carl-Neuberg-Strasse 1, 30625 Hannover, Germany, , , , , , DE

    G. Büsche

  4. Schwerpunktpraxis Hämatologie/Onkologie, Calenberger Esplanade 1, 30169 Hannover, Germany, , , , , , DE

    B. Gaede

Authors
  1. P. Schöffski
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  2. A. Ganser
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  3. U. Pascheberg
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  4. G. Büsche
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  5. B. Gaede
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  6. B. Hertenstein
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Additional information

Received: 26 June 1999 / Accepted: 3 September 1999

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Schöffski, P., Ganser, A., Pascheberg, U. et al. Complete haematological and cytogenetic response to interferon alpha-2a of a myeloproliferative disorder with eosinophilia associated with a unique t(4;7) aberration. Ann Hematol 79, 95–98 (2000). https://doi.org/10.1007/s002770050018

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  • DOI: https://doi.org/10.1007/s002770050018

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