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Ruxolitinib therapy is associated with improved renal function in patients with primary myelofibrosis

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Abstract

Recent evidence suggests that renal dysfunction may be a direct consequence of primary myelofibrosis (PMF). We performed a retrospective analysis of 100 patients with previously untreated PMF, receiving frontline treatment with single agent ruxolitinib, and compared them to 105 patients, receiving frontline treatment with a non-ruxolitinib-based therapy, matched by age, sex, DIPSS plus, and estimated glomerular filtration rate (eGFR). Use of ruxolitinib associated with a significantly higher rate of renal improvement (RI) > 10% (73% vs 50%, p = 0.01) confirmed on multivariate analysis (MVA) [odds ratio 3, 95% confidence interval (CI) 1.6–5.5, p < 0.001]. After a median follow-up of 41 months (range, 1–159 months), median failure-free survival (FFS) was 14 months (range, 1–117 months). Achievement of a RI > 10% maintained its independent association with prolonged FFS on MVA (hazard ratio 1.4, 95% CI 1.1–2, p = 0.02). Ruxolitinib can significantly improve renal function in patients with PMF, significantly impacting failure-free survival.

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Authors and Affiliations

  1. Division of Cancer Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX, USA

    Paolo Strati

  2. Institute of Academic Medicine and Weill Cornell Medical College, Houston Methodist Cancer Center, Houston, TX, USA

    Maen Abdelrahim

  3. Division of Nephrology, Department of Medicine, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, California, USA

    Umut Selamet

  4. Section of Nephrology, Division of Internal Medicine, The University of Texas MD Anderson Cancer Center, 1515 Holcombe Blvd, Unit 1468, Houston, TX, 77030, USA

    Valda D. Page & Ala Abudayyeh

  5. Department of Leukemia, The University of Texas MD Anderson Cancer Center, 1515 Holcombe Blvd, Unit 428, Houston, TX, 77030, USA

    Sherry A. Pierce & Srdan Verstovsek

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  1. Paolo Strati
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  2. Maen Abdelrahim
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  3. Umut Selamet
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  4. Valda D. Page
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  7. Ala Abudayyeh
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Contributions

PS designed the study, analyzed data, and wrote the paper; SV provided clinical care to patients and coauthored the paper; MA and US provided clinical care to patients and coauthored the paper; VDP and SAP collected clinical data and coauthored the paper; AA designed the study, analyzed the data, provided clinical care to patients, and wrote the paper.

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Correspondence to Srdan Verstovsek or Ala Abudayyeh.

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Strati, P., Abdelrahim, M., Selamet, U. et al. Ruxolitinib therapy is associated with improved renal function in patients with primary myelofibrosis. Ann Hematol 98, 1611–1616 (2019). https://doi.org/10.1007/s00277-019-03708-9

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