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Validation of the Marginal Zone Lymphoma International Prognostic Index

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Abstract

The Marginal Zone Lymphoma International Prognostic Index (MALT-IPI) was recently developed for use in patients with mucosa-associated lymphoid tissue (MALT) lymphoma based on age, serum lactate dehydrogenase level, and Ann Arbor stage. In this study, we aimed to validate the MALT-IPI. A total of 455 MALT lymphoma patients were included in this study from between January 2005 and February 2017. Event-free survival (EFS), progression-free survival (PFS), cause-specific survival (CSS), and overall survival (OS) were the primary outcomes. Of the 455 patients, MALT-IPI low-, intermediate-, and high-risk groups included 309 (67.9%), 126 (27.7%), and 20 (4.4%) individuals, respectively. When comparing the low-risk group (L MALT-IPI) with the intermediate–high-risk group (I-H MALT-IPI), EFS, PFS, CSS, and OS were significantly different (p = 0.000, p = 0.000, p = 0.027, and p = 0.037). The International Prognostic Index and the Follicular Lymphoma International Prognostic Index failed to predict the prognosis of MALT lymphoma. Use of the MALT-IPI significantly differentiated L MALT-IPI from I-H MALT-IPI with respect to EFS, PFS, CSS, and OS. MALT-IPI is a valuable tool for the prediction of MALT lymphoma prognosis.

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Authors and Affiliations

  1. Division of Hematology-Oncology, Department of Medicine, Samsung Medical Center, School of Medicine, Sungkyunkwan Universitye, 81 Irwon-ro, Gangnam-gu, Seoul, 06351, South Korea

    Joohyun Hong, Seok Jin Kim & Won Seog Kim

  2. Department of Pathology, Samsung Medical Center, School of Medicine, Sungkyunkwan University, Seoul, South Korea

    Junhun Cho & Young Hye Ko

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  1. Joohyun Hong
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  2. Junhun Cho
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  3. Young Hye Ko
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  5. Won Seog Kim
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Correspondence to Won Seog Kim.

Ethics declarations

This study was approved by the institutional review board (IRB) of Samsung Medical Center in Seoul, Korea (IRB number 2018-02-076).

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The authors declare that they have no conflict of interest.

Ethical approval

All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards.

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Informed consent was obtained from all individual participants included in the study.

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Hong, J., Cho, J., Ko, Y.H. et al. Validation of the Marginal Zone Lymphoma International Prognostic Index. Ann Hematol 98, 457–464 (2019). https://doi.org/10.1007/s00277-018-3516-1

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  • DOI: https://doi.org/10.1007/s00277-018-3516-1

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