References
Marzocchi G, Castagnetti F, Luatti S, Baldazzi C, Stacchini M, Gugliotta G et al (2011) Variant Philadelphia translocations: molecular-cytogenetic characterization and prognostic influence on frontline imatinib therapy, a GIMEMA Working Party on CML analysis. Blood 117(25):6793–6800
Gorusu M, Benn P, Li Z, Fang M (2007) On the genesis and prognosis of variant translocations in chronic myeloid leukemia. Cancer Genet Cytogenet 173(2):97–106
Johansson B, Fioretos T, Mitelman F (2002) Cytogenetic and molecular genetic evolution of chronic myeloid leukemia. Acta Haematol 107(2):76–94
Luatti S, Castagnetti F, Marzocchi G, Baldazzi C, Gugliotta G, Iacobucci I et al (2012) Additional chromosomal abnormalities in Philadelphia-positive clone: adverse prognostic influence on frontline imatinib therapy: a GIMEMA Working Party on CML analysis. Blood 120(4):761–767
Chen Z, Cortes JE, Jorgensen JL, Wang W, Yin CC, You MJ et al (2016) Differential impact of additional chromosomal abnormalities in myeloid vs lymphoid blast phase of chronic myeloid leukemia in the era of tyrosine kinase inhibitor therapy. Leukemia 30(7):1606-1609
Chen Z, Shao C, Wang W, Zuo Z, Mou X, Hu SJ et al. (2016) Cytogenetic landscape and impact in blast phase of chronic myeloid leukemia in the era of tyrosine kinase inhibitor therapy. Leukemia
Wang W, Cortes JE, Tang G, Khoury JD, Wang S, Bueso-Ramos CE et al. (2016) Risk stratification of chromosomal abnormalities in chronic myelogenous leukemia in the era of tyrosine kinase inhibitor therapy. Blood
Wang W, Cortes JE, Lin P, Beaty MW, Ai D, Amin HM et al (2015) Clinical and prognostic significance of 3q26.2 and other chromosome 3 abnormalities in CML in the era of tyrosine kinase inhibitors. Blood 126(14):1699–1706
Wang W, Cortes JE, Lin P, Khoury JD, Ai D, Tang Z et al (2015) Impact of trisomy 8 on treatment response and survival of patients with chronic myelogenous leukemia in the era of tyrosine kinase inhibitors. Leukemia 29(11):2263–2266
Sinclair PB, Nacheva EP, Leversha M, Telford N, Chang J, Reid A et al (2000) Large deletions at the t(9;22) breakpoint are common and may identify a poor-prognosis subgroup of patients with chronic myeloid leukemia. Blood 95(3):738–743
Potter AM, Watmore AE, Cooke P, Lilleyman JS, Sokol RJ (1981) Significance of non-standard Philadelphia chromosomes in chronic granulocytic leukaemia. Br J Cancer 44(1):51–54
Richebourg S, Eclache V, Perot C, Portnoi MF, Van den Akker J, Terre C et al (2008) Mechanisms of genesis of variant translocation in chronic myeloid leukemia are not correlated with ABL1 or BCR deletion status or response to imatinib therapy. Cancer Genet Cytogenet 182(2):95–102
El-Zimaity MM, Kantarjian H, Talpaz M, O’Brien S, Giles F, Garcia-Manero G et al (2004) Results of imatinib mesylate therapy in chronic myelogenous leukaemia with variant Philadelphia chromosome. Br J Haematol 125(2):187–195
Fabarius A, Leitner A, Hochhaus A, Muller MC, Hanfstein B, Haferlach C et al (2011) Impact of additional cytogenetic aberrations at diagnosis on prognosis of CML: long-term observation of 1151 patients from the randomized CML Study IV. Blood 118(26):6760–6768
Haigh S, Cuthbert G (2004) Fluorescence in situ hybridization characterization of different cryptic BCR-ABL rearrangements in chronic myeloid leukemia. Cancer Genet Cytogenet 155(2):132–137
Morel F, Herry A, Le Bris MJ, Morice P, Bouquard P, Abgrall JF et al (2003) Contribution of fluorescence in situ hybridization analyses to the characterization of masked and complex Philadelphia chromosome translocations in chronic myelocytic leukemia. Cancer Genet Cytogenet 147(2):115–120
Authors’ contribution
ZG and SH designed the study, collected and analyzed data, and wrote the manuscript. All authors read and approved the final manuscript.
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The study is approved by the Institutional Review Board at the University of Texas MD Anderson Cancer Center.
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The authors declare that they have no conflict of interest.
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An erratum to this article is available at http://dx.doi.org/10.1007/s00277-017-3025-7.
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Gong, Z., Zheng, L., Tang, Z. et al. Role of complexity of variant Philadelphia chromosome in chronic myeloid leukemia in the era of tyrosine kinase inhibitor therapy. Ann Hematol 96, 501–504 (2017). https://doi.org/10.1007/s00277-016-2892-7
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DOI: https://doi.org/10.1007/s00277-016-2892-7