Skip to main content

Advertisement

SpringerLink
Log in

Mismatched unrelated hematopoietic stem cell transplantation with post-transplant cyclophosphamide for high-risk acute myeloid leukemia

  • Letter to the Editor
  • Published:
Annals of Hematology Aims and scope Submit manuscript

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

References

  1. Bashey A, Zhang X, Sizemore CA, Manion K, Brown S, Holland HK, Morris LE, Solomon SR (2013) T-cell-replete HLA-haploidentical hematopoietic transplantation for hematologic malignancies using post-transplantation cyclophosphamide results in outcomes equivalent to those of contemporaneous HLA-matched related and unrelated donor transplantation. J Clin Oncol 31(10):1310–1316. doi:10.1200/JCO.2012.44.3523

    Article  CAS  PubMed  Google Scholar 

  2. Luznik L, Fuchs EJ (2010) High-dose, post-transplantation cyclophosphamide to promote graft-host tolerance after allogeneic hematopoietic stem cell transplantation. Immunol Res 47(1–3):65–77. doi:10.1007/s12026-009-8139-0

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  3. Raiola AM, Dominietto A, di Grazia C, Lamparelli T, Gualandi F, Ibatici A, Bregante S, Van Lint MT, Varaldo R, Ghiso A, Gobbi M, Carella AM, Signori A, Galaverna F, Bacigalupo A (2014) Unmanipulated haploidentical transplants compared with other alternative donors and matched sibling grafts. Biol Blood Marrow Transplant 20(10):1573–1579. doi:10.1016/j.bbmt.2014.05.029

    Article  PubMed  Google Scholar 

  4. McCurdy SR, Kanakry JA, Showel MM, Tsai HL, Bolanos-Meade J, Rosner GL, Kanakry CG, Perica K, Symons HJ, Brodsky RA, Gladstone DE, Huff CA, Pratz KW, Prince GT, Dezern AE, Gojo I, Matsui WH, Borrello I, McDevitt MA, Swinnen LJ, Smith BD, Levis MJ, Ambinder RF, Luznik L, Jones RJ, Fuchs EJ, Kasamon YL (2015) Risk-stratified outcomes of nonmyeloablative HLA-haploidentical BMT with high-dose posttransplantation cyclophosphamide. Blood 125(19):3024–3031. doi:10.1182/blood-2015-01-623991

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  5. Ciurea SO, Zhang MJ, Bacigalupo AA, Bashey A, Appelbaum FR, Aljitawi OS, Armand P, Antin JH, Chen J, Devine SM, Fowler DH, Luznik L, Nakamura R, O’Donnell PV, Perales MA, Pingali SR, Porter DL, Riches MR, Ringden OT, Rocha V, Vij R, Weisdorf DJ, Champlin RE, Horowitz MM, Fuchs EJ, Eapen M (2015) Haploidentical transplant with posttransplant cyclophosphamide vs matched unrelated donor transplant for acute myeloid leukemia. Blood 126(8):1033–1040. doi:10.1182/blood-2015-04-639831

    Article  CAS  PubMed  Google Scholar 

  6. Kanakry CG, Tsai HL, Bolanos-Meade J, Smith BD, Gojo I, Kanakry JA, Kasamon YL, Gladstone DE, Matsui W, Borrello I, Huff CA, Swinnen LJ, Powell JD, Pratz KW, DeZern AE, Showel MM, McDevitt MA, Brodsky RA, Levis MJ, Ambinder RF, Fuchs EJ, Rosner GL, Jones RJ, Luznik L (2014) Single-agent GVHD prophylaxis with posttransplantation cyclophosphamide after myeloablative, HLA-matched BMT for AML, ALL, and MDS. Blood 124(25):3817–3827. doi:10.1182/blood-2014-07-587477

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  7. Pidala J, Lee SJ, Ahn KW, Spellman S, Wang HL, Aljurf M, Askar M, Dehn J, Fernandez Vina M, Gratwohl A, Gupta V, Hanna R, Horowitz MM, Hurley CK, Inamoto Y, Kassim AA, Nishihori T, Mueller C, Oudshoorn M, Petersdorf EW, Prasad V, Robinson J, Saber W, Schultz KR, Shaw B, Storek J, Wood WA, Woolfrey AE, Anasetti C (2014) Nonpermissive HLA-DPB1 mismatch increases mortality after myeloablative unrelated allogeneic hematopoietic cell transplantation. Blood 124(16):2596–2606. doi:10.1182/blood-2014-05-576041

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  8. Raiola AM, Dominietto A, Ghiso A, Di Grazia C, Lamparelli T, Gualandi F, Bregante S, Van Lint MT, Geroldi S, Luchetti S, Ballerini F, Miglino M, Varaldo R, Bacigalupo A (2013) Unmanipulated haploidentical bone marrow transplantation and posttransplantation cyclophosphamide for hematologic malignancies after myeloablative conditioning. Biol Blood Marrow Transplant 19(1):117–122. doi:10.1016/j.bbmt.2012.08.014

    Article  CAS  PubMed  Google Scholar 

  9. Bayraktar UD, Milton DR, Guindani M, Rondon G, Chen J, Al-Atrash G, Rezvani K, Champlin R, Ciurea SO (2015) Optimal threshold and time of absolute lymphocyte count assessment for outcome prediction after bone marrow transplantation. Biol Blood Marrow Transplant. doi:10.1016/j.bbmt.2015.10.020

    PubMed  Google Scholar 

  10. Piemontese S, Ciceri F, Labopin M, Bacigalupo A, Huang H, Santarone S, Gorin NC, Koc Y, Wu D, Beelen D, Tischer J, Ehninger G, Arcese W, Nagler A, Mohty M (2015) A survey on unmanipulated haploidentical hematopoietic stem cell transplantation in adults with acute leukemia. Leukemia 29(5):1069–1075. doi:10.1038/leu.2014.336

    Article  CAS  PubMed  Google Scholar 

Download references

Acknowledgments

We are grateful to the Alfred und Angelika Gutermuth-Stiftung and the KGF Stiftung for support of our transplant program.

Author information

Authors and Affiliations

  1. Department of Medicine II, Hematology and Oncology, University Hospital Frankfurt, Goethe University, Theodor-Stern-Kai 7, 60590, Frankfurt am Main, Germany

    Sarah Lindner, Tobias Berg, Julia Riemann, Salem Ajib, Zuzana Jedlickova, Saskia Gueller, Fabian Lang, Hans Martin, Hubert Serve & Gesine Bug

  2. Universita’ Cattolica del Sacro Cuore, Fondazione Policlinico Universitario Gemelli, Rome, Italy

    Andrea Bacigalupo

Authors
  1. Sarah Lindner
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Tobias Berg
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Julia Riemann
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Salem Ajib
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Zuzana Jedlickova
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. Saskia Gueller
    View author publications

    You can also search for this author in PubMed Google Scholar

  7. Fabian Lang
    View author publications

    You can also search for this author in PubMed Google Scholar

  8. Hans Martin
    View author publications

    You can also search for this author in PubMed Google Scholar

  9. Hubert Serve
    View author publications

    You can also search for this author in PubMed Google Scholar

  10. Andrea Bacigalupo
    View author publications

    You can also search for this author in PubMed Google Scholar

  11. Gesine Bug
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Gesine Bug.

Ethics declarations

Conflict of interest

The authors declare that they have no conflict of interest.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Lindner, S., Berg, T., Riemann, J. et al. Mismatched unrelated hematopoietic stem cell transplantation with post-transplant cyclophosphamide for high-risk acute myeloid leukemia. Ann Hematol 95, 1023–1025 (2016). https://doi.org/10.1007/s00277-016-2652-8

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s00277-016-2652-8

Keywords

Search

Navigation