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MicroRNAs as biomarkers for graft-versus-host disease following allogeneic stem cell transplantation

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Abstract

Allogeneic hematopoietic stem cell transplantation (HCT) is a well-established treatment for many malignant and non-malignant hematological disorders. As frequent complication in up to 50 % of all patients, graft-versus-host disease (GVHD) is still the main cause for morbidity and non-relapse mortality. Diagnosis of GVHD is usually done clinically, even though confirmation by pathology is often used to support the clinical findings. Effective treatment requires intensified immunosuppression as early as possible. Although several promising biomarkers have been proposed for an early diagnosis, no internationally recognized consensus has yet been established. Here, microRNAs (miRs) represent an interesting tool since miRs have been recently reported to be an important regulator of various cells, including immune cells such as T cells. Therefore, we could assume that miRs play a key role in the pathogenesis of acute GVHD, and their detection might be an interesting possibility in the early diagnosis and monitoring of acute GVHD. Recent studies additionally demonstrated the implication of miRs in the pathogenesis of acute GVHD. In this review, we aim to summarize the previous reports of miRs, focusing on the pathogenesis of acute GVHD and possible implications in diagnostic approaches.

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Acknowledgments

The current paper is supported by an international grant, Romania–European Economical Space (Norway), which was awarded to Andrei Cucuianu and Ciprian Tomuleasa (contract 1/16.01.2014). This paper was published under the frame of European Social Fund, Human Resources Development Operational Programme 2007–2013, Project number POSDRU 159/1.5/138776. The authors gratefully acknowledge the help of Mrs Cornelia Braicu with the figure drawing.

Conflict of interest

The authors declare that they have no conflict of interest.

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Authors and Affiliations

  1. Iuliu Hatieganu University of Medicine and Pharmacy, Bulevardul 21 Decembrie 1918 Nr. 73, 400124, Cluj Napoca, Romania

    Ciprian Tomuleasa, Andrei Cucuianu, Valentina Pileczki, Bobe Petrushev, Sonia Selicean, Ioana Berindan-Neagoe & Alexandru Irimie

  2. Department of Hematology, Ion Chiricuta Oncology Institute, Bulevardul 21 Decembrie 1918 Nr. 73, 400124, Cluj Napoca, Romania

    Ciprian Tomuleasa, Andrei Cucuianu & Delia Dima

  3. Division of Hematopoietic Stem Cell Transplantation, National Cancer Center Hospital, Tokyo, Japan

    Shigeo Fuji

  4. Division of Hematology, Universitätsklinikum Würzburg Medizinische Klinik und Poliklinik II, Würzburg, Germany

    Markus Kapp & Hermann Einsele

  5. Department of Stem Cell Transplantation, Fundeni Clinical Institute, Bucharest, Romania

    Alina Tanase

  6. Department of Functional Genomics, Ion Chiricuta Oncology Institute, Cluj Napoca, Romania

    Ioana Berindan-Neagoe

  7. Department of Surgery, Ion Chiricuta Oncology Institute, Cluj Napoca, Romania

    Alexandru Irimie

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  1. Ciprian Tomuleasa
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  2. Shigeo Fuji
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Correspondence to Ciprian Tomuleasa.

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Tomuleasa, C., Fuji, S., Cucuianu, A. et al. MicroRNAs as biomarkers for graft-versus-host disease following allogeneic stem cell transplantation. Ann Hematol 94, 1081–1092 (2015). https://doi.org/10.1007/s00277-015-2369-0

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  • DOI: https://doi.org/10.1007/s00277-015-2369-0

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