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New prognostic model for extranodal natural killer/T cell lymphoma, nasal type

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Abstract

Extranodal natural killer/T cell lymphoma, nasal type (ENKTL) is an aggressive disease with a poor prognosis, requiring risk stratification in affected patients. We designed a new prognostic model specifically for ENKTL to identify high-risk patients who need more aggressive therapy. We retrospectively reviewed 158 patients who were newly diagnosed with ENKTL. The estimated 5-year overall survival rate was 39.4 %. Independent prognostic factors included total protein (TP) <60 g/L, fasting blood glucose (FBG) >100 mg/dL, and Korean Prognostic Index (KPI) score ≥2. We constructed a new prognostic model by combining these prognostic factors: group 1 (64 cases (41.0 %)), no adverse factors; group 2 (58 cases (37.2 %)), one adverse factor; and group 3 (34 cases (21.8 %)), two or three adverse factors. The 5-year overall survival (OS) rates of these groups were 66.7, 23.0, and 5.9 %, respectively (p < 0.001). Our new prognostic model had a better prognostic value than did the KPI model alone (p < 0.001). Our proposed prognostic model for ENKTL, including the newly identified prognostic indicators, TP and FBG, demonstrated a balanced distribution of patients into different risk groups with better prognostic discrimination compared with the KPI model alone.

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Acknowledgments

This work was supported by the National Nature Science Foundation of China (81372883 and 81001052), Science and Technology Planning Project of Guangdong Province, China (2011B031800222), Young Talents Project of Sun Yat-sen University Cancer Center (to Cai Qingqing), Young Talents Project of Sun Yat-sen University (to Cai Qingqing), and Natural Science Foundation of Guangdong Province, China (8151008901000043). This research was also partly supported by the NIH through MD Anderson's Cancer Center Support Grant CA016672.

Conflict of interest

The authors declare no conflicts of interest.

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Authors and Affiliations

  1. Department of Medical Oncology, Sun Yat-Sen University Cancer Center, 651 Dong Feng RD East, Guangzhou, 510060, People’s Republic of China

    Qingqing Cai, Huiqiang Huang, Tongyu Lin & Wenqi Jiang

  2. State Key Laboratory of Oncology in Southern China, 651 Dong Feng RD East, Guangzhou, 510060, People’s Republic of China

    Qingqing Cai, Xiaolin Luo, Huiqiang Huang, Tongyu Lin, Wenqi Jiang & Zhongjun Xia

  3. Collaborative Innovation Center of Cancer Medicine, 651 Dong Feng RD East, Guangzhou, 510060, People’s Republic of China

    Qingqing Cai, Xiaolin Luo, Huiqiang Huang, Tongyu Lin, Wenqi Jiang & Zhongjun Xia

  4. Department of Gynecologic Oncology, Sun Yat-sen University Cancer Center, Guangzhou, China

    Xiaolin Luo

  5. Health Management Center, Guangdong General Hospital and Guangdong Academy of Medical Sciences, Guangzhou, China

    Guanrong Zhang

  6. Department of Cardiology, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, China

    Hui Huang

  7. Guangdong Province Key Laboratory of Arrhythmia and Electrophysiology, Guangzhou, China

    Hui Huang

  8. Department of Hematological Oncology, Sun Yat-sen University Cancer Center, Guangzhou, China

    Zhongjun Xia

  9. Department of Hematopathology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA

    Ken H. Young

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  1. Qingqing Cai
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  2. Xiaolin Luo
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  5. Hui Huang
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  9. Ken H. Young
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Corresponding author

Correspondence to Qingqing Cai.

Additional information

Qingqing Cai, Xiaolin Luo, and Guanrong Zhang equally contributed to this work.

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Cai, Q., Luo, X., Zhang, G. et al. New prognostic model for extranodal natural killer/T cell lymphoma, nasal type. Ann Hematol 93, 1541–1549 (2014). https://doi.org/10.1007/s00277-014-2089-x

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  • DOI: https://doi.org/10.1007/s00277-014-2089-x

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