References
Schnittger S, Bacher U, Kern W, Haferlach T, Hertenstein B, Haferlach C (2008) A new case with rare e6a2 BCR-ABL fusion transcript developing two new resistance mutations during imatinib mesylate, which were replaced by T315I after subsequent dasatinib treatment. Leukemia 22(4):856–858
Torres F, Ivanova-Dragoeva A, Pereira M, Veiga J, Rodrigues AS, Sousa AB, Tavares P, Fernandes AR (2007) An e6a2 BCR-ABL fusion transcript in a CML patient having an iliac chloroma at initial presentation. Leuk Lymphoma 48(5):1034–1037
Colla S, Sammarelli G, Voltolini S, Crugnola M, Sebastio P, Giuliani N (2004) e6a2 BCR-ABL transcript in chronic myeloid leukemia: is it associated with aggressive disease? Haematologica 89(5):611–613
Hochhaus A, Reiter A, Skladny H, Melo JV, Sick C, Berger U, Guo JQ, Arlinghaus RB, Hehlmann R, Goldman JM, Cross NC (1996) A novel BCR-ABL fusion gene (e6a2) in a patient with Philadelphia chromosome-negative chronic myelogenous leukemia. Blood 88(6):2236–2240
Dupont M, Jourdan E, Chiesa J (2000) Identification of E6A2 BCR-ABL fusion in a Philadelphia-positive CML. Leukemia 14(11):2011–2012
Schultheis B, Wang L, Clark RE, Melo JV (2003) BCR-ABL with an e6a2 fusion in a CML patient diagnosed in blast crisis. Leukemia 17(10):2054–2055
Roti G, La Starza R, Gorello P, Gottardi E, Crescenzi B, Martelli MF, Mecucci C (2005) e6a2 BCR/ABL1 fusion with cryptic der(9)t(9;22) deletions in a patient with chronic myeloid leukemia. Haematologica 90(8):1139–1141
Popovici C, Cailleres S, David M, Lafage-Pochitaloff M, Sainty D, Mozziconacci MJ (2005) E6a2 BCR-ABL fusion with BCR exon 5-deleted transcript in a Philadelphia positive CML responsive to Imatinib. Leuk Lymphoma 46(9):1375–1377
Breccia M, Cannella L, Diverio D, Streponi P, Nanni M, Stefanizzi C, Natalino F, Mecarocci S, Alimena G (2008) Isolated thrombocytosis as first sign of chronic myeloid leukemia with e6a2 BCR/ABL fusion transcript, JAK2 negativity and complete response to imatinib. Leuk Res 32(1):177–180
Vefring HK, Gruber FX, Wee L, Hovland R, Hjorth-Hansen H, Gedde Dahl T, Meyer P (2009) Chronic myelogenous leukemia with the e6a2 BCR-ABL and lacking imatinib response: presentation of two cases. Acta Haematol 122(1):11–16
Langabeer SE, Crampe M, Kelly J, Fadalla K, Connaghan G, Conneally E (2010) Nilotinib and allogeneic stem cell transplantation in a chronic myeloid leukemia patient with e6a2 and e1a2 BCR-ABL transcripts. Leuk Res 34(8):e204–e205
van Dongen JJ, Macintyre EA, Gabert JA, Delabesse E, Rossi V, Saglio G, Gottardi E, Rambaldi A, Dotti G, Griesinger F, Parreira A, Gameiro P, Diaz MG, Malec M, Langerak AW, San Miguel JF, Biondi A (1999) Standardized RT-PCR analysis of fusion gene transcripts from chromosome aberrations in acute leukemia for detection of minimal residual disease. Report of the BIOMED-1 Concerted Action: investigation of minimal residual disease in acute leukemia. Leukemia 13(12):1901–1928
Valent P, Lion T, Wolf D, Sillaber C, Agis H, Petzer A, Lang A, Kahls P, Geissler D, Greil R, Linkesch W, Burgstaller S, Thaler J, Gastl G (2008) Diagnostic algorithms, monitoring, prognostication, and therapy in chronic myeloid leukemia (CML): a proposal of the Austrian CML platform. Wien Klin Wochenschr 120(21–22):697–709
Cross NC, Melo JV, Feng L, Goldman JM (1994) An optimized multiplex polymerase chain reaction (PCR) for detection of BCR-ABL fusion mRNAs in haematological disorders. Leukemia 8(1):186–189
Jinawath N, Norris-Kirby A, Smith BD, Gocke CD, Batista DA, Griffin CA, Murphy KM (2009) A rare e14a3 (b3a3) BCR-ABL fusion transcript in chronic myeloid leukemia. Diagnostic challenges in clinical laboratory practice. J Mol Diagn 11(4):359–363
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PV is a senior clinical investigator of the Fund for Scientific Research-Flanders (Belgium) (FWO Vlaanderen).
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Beel, K.A., Lemmens, J., Vranckx, H. et al. CML with e6a2 BCR-ABL1 transcript: an aggressive entity?. Ann Hematol 90, 1241–1243 (2011). https://doi.org/10.1007/s00277-011-1169-4
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DOI: https://doi.org/10.1007/s00277-011-1169-4