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Peripheral blood stem cell collection in elderly patients

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Abstract

Intensive treatments like autologous blood stem cell transplantations are standard consolidation treatments for lymphoma and myeloma in young people. The upper age limit for these procedures is constantly increasing. Instead of studying the impact of aging on harvesting peripheral blood stem cells (PBSC), we performed a retrospective study to explore the feasibility of collecting stem cells from patients older than 65 years and compared the efficacy to harvest in younger patients. During a period of 7 years, we identified 108 patients with myeloma or lymphoma who were older than 65 years who underwent PBSC collection. Only eight patients failed to produce a successful harvest. The majority of patients only needed one apheresis (71%). There was a median number of 5.3 × 106 CD34+ cells/kg. Our study demonstrated that older patients can also undergo PBSC harvests similar to younger patients.

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Authors and Affiliations

  1. Department of Clinical Haematology, Institute of Cancerology and Hematology, CHU Morvan, Avenue Foch, 29609, Brest, France

    Adrian Tempescul, Jean-Christophe Ianotto & Christian Berthou

  2. EFS Bretagne, Brest, France

    Elisabeth Hardy & Francoise Quivoron

  3. Department of Clinical Hematology, Cluj Oncologic Institute, Cluj-Napoca, Romania

    Ljubomir Petrov

  4. Department of Clinical Haematology, Institute of Cancerology and Hematology, University Hospital Brest, 2 Avenue Foch, 29609, Brest cedex, France

    Adrian Tempescul

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  1. Adrian Tempescul
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  2. Jean-Christophe Ianotto
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  3. Elisabeth Hardy
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  4. Francoise Quivoron
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  5. Ljubomir Petrov
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  6. Christian Berthou
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Correspondence to Adrian Tempescul.

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Tempescul, A., Ianotto, JC., Hardy, E. et al. Peripheral blood stem cell collection in elderly patients. Ann Hematol 89, 317–321 (2010). https://doi.org/10.1007/s00277-009-0812-9

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  • DOI: https://doi.org/10.1007/s00277-009-0812-9

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