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Bulky extramedullary hematopoiesis is not a rare complication of congenital dyserythropoietic anemia

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Abstract

Bulky extramedullary hematopoiesis, usually detected in the thorax by imaging techniques, is a well-known complication in many types of congenital anemias. Here, we describe 12 cases of congenital dyserythropoietic anemia with extramedullary hematopoiesis which was always located in the paravertebral space of the thoracic spine and in other paraspinal regions in a few cases. All bulks were originally detected in chest radiographs and confirmed by imaging techniques such as computed tomography and/or magnetic resonance imaging. In some cases, thoracotomy was performed for suspected malignancy. Although the true prevalence is not known, paravertebral masses in patients with CDA of any type are not uncommon and should be the first differential diagnosis considered when masses adjacent to the spine are detected in this disorder.

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Authors and Affiliations

  1. Medizinische Klinik III, Universitätsklinikum Ulm, Ulm, Germany

    Hermann Heimpel

  2. Klinik für Hämatologie, Universität Essen, Essen, Germany

    Ulrich Dührsen

  3. Fachpraxis für Lungenkrankheiten, Weinheim, Germany

    P. Hofbauer

  4. Abteilung für Hämatologie and Hämatologisches Zentralaboratoratorium, Universitätsklinik und Universität Bern, Bern, Switzerland

    V. Rigamonti-Wermlinger & Max Solenthaler

  5. Klinik für Onkologie, Krankenhaus der barmherzigen Brüder, Regensburg, Germany

    Ernst-Dietrich Kreuser

  6. Institut für klinische Transfusionsmedizin und Immungenetik und Institut für Transfusionsmedizin, Universitätsklinikum Ulm, Ulm, Germany

    Klaus Schwarz

  7. Klinik für Diagnostische und Interventionelle Radiologie, Universitätsklinikum Ulm, Ulm, Germany

    S. Pauls

Authors
  1. Hermann Heimpel
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  2. Ulrich Dührsen
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  3. P. Hofbauer
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  4. V. Rigamonti-Wermlinger
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  5. Ernst-Dietrich Kreuser
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  6. Klaus Schwarz
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  8. S. Pauls
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Correspondence to Hermann Heimpel.

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Heimpel, H., Dührsen, U., Hofbauer, P. et al. Bulky extramedullary hematopoiesis is not a rare complication of congenital dyserythropoietic anemia. Ann Hematol 88, 937–941 (2009). https://doi.org/10.1007/s00277-009-0735-5

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  • DOI: https://doi.org/10.1007/s00277-009-0735-5

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