Abstract
Dicentric (9;20) [dic(9;20)] is a rare recurring chromosome abnormality in leukemia patients. In this study, we report three adult patients with acute lymphoblastic leukemia (ALL) with dic(9;20) anomaly. All three patients were diagnosed as cluster of differentiation 10 (CD10) positive B cell ALL, achieved complete remission after induction chemotherapy, and died of leukemia relapse within 1 year after diagnosis. Specimens for chromosome analysis were prepared by direct method and/or short-time culture of bone marrow cells. Karyotyping was performed by R-banding technique. Dual-color fluorescence in situ hybridization (FISH) was performed using chromosome 9 and chromosome 20-specific centromeric probes. Karyotype analysis showed that all three patients had dic(9;20)(p11–13;q11), in which the dicentric nature of the derived chromosome was confirmed by interphase FISH. Dicentric (9;20)(p11–13;q11) may be specifically associated with ALL, and monosomy 20 may be a pointer to dic(9;20) in ALL. The prognostic significance of dic(9;20) in adult patients with ALL remains to be determined.
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Acknowledgment
Thanks to Prof. Yongquan Xue and Yafang Wu from the Affiliated Hospital of Soochow University, Jiangsu Institute of Hematology, Suzhou, People’s Republic China for their help in FISH analysis.
X. Song and S. Gong contributed equally to this work.
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Song, X., Gong, S., Yang, J. et al. Clinical and molecular cytogenetic characteristics of dic(9;20) in adult acute lymphoblastic leukemia: a case report of three patients. Ann Hematol 86, 347–351 (2007). https://doi.org/10.1007/s00277-007-0255-0
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DOI: https://doi.org/10.1007/s00277-007-0255-0