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Extended follow-up of outcome measures in multiple myeloma patients treated on a phase I study with bortezomib and pegylated liposomal doxorubicin

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Abstract

A phase I study of a combination of the proteasome inhibitor bortezomib and pegylated liposomal doxorubicin showed significant anti-tumor activity against advanced multiple myeloma, with 36% of patients achieving a complete or near-complete response and 73% having a partial response or better. Given this encouraging efficacy, it was therefore of interest to update the prior experience and define parameters such as time to progression, time to retreatment, and overall survival. Additional follow-up was collected on all evaluable multiple myeloma patients and revealed a median time to progression of 9.3 months versus 3.8 months on whatever had been the patient’s prior therapy. Time to retreatment was prolonged from 5.9 months after the patient’s prior therapy to 24.2 months after bortezomib with pegylated liposomal doxorubicin. The median overall survival after therapy with bortezomib and pegylated liposomal doxorubicin was 38.3 months. These findings compare favorably with results reported for bortezomib alone and support the possibility that the bortezomib/pegylated liposomal doxorubicin regimen may provide superior efficacy against relapsed/refractory multiple myeloma.

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Acknowledgment

The authors would like to thank and dedicate this paper to all the patients whose participation in the phase I study made this research possible.

S.E.B. was supported in part by the Doris Duke Charitable Foundation (Clinical Research Fellows) and the General Clinical Research Centers program of the Division of Research Resources, National Institutes of Health (RR-000046). R.Z.O., a Leukemia and Lymphoma Society Mansbach Foundation Scholar in Clinical Research, would like to acknowledge support from the Leukemia and Lymphoma Society (6096-07), the Multiple Myeloma Research Foundation, and the National Cancer Institute (RO1 CA102278).

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Authors and Affiliations

  1. University of North Carolina at Chapel Hill School of Medicine, Chapel Hill, NC, USA

    Suzanne E. Biehn, E. Claire Dees & Robert Z. Orlowski

  2. Department of Biostatistics, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA

    Dominic T. Moore

  3. Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, CB # 7295, Mason Farm Road, Chapel Hill, NC, 27599-7295, USA

    Dominic T. Moore, Peter M. Voorhees, Reynaldo A. Garcia, Mary Jo Lehman, E. Claire Dees & Robert Z. Orlowski

  4. Division of Hematology/Oncology, Department of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA

    Peter M. Voorhees, E. Claire Dees & Robert Z. Orlowski

  5. Department of Pharmacology, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA

    Robert Z. Orlowski

Authors
  1. Suzanne E. Biehn
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  2. Dominic T. Moore
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  3. Peter M. Voorhees
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  4. Reynaldo A. Garcia
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  5. Mary Jo Lehman
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  6. E. Claire Dees
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  7. Robert Z. Orlowski
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Correspondence to Robert Z. Orlowski.

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Biehn, S.E., Moore, D.T., Voorhees, P.M. et al. Extended follow-up of outcome measures in multiple myeloma patients treated on a phase I study with bortezomib and pegylated liposomal doxorubicin. Ann Hematol 86, 211–216 (2007). https://doi.org/10.1007/s00277-006-0220-3

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  • DOI: https://doi.org/10.1007/s00277-006-0220-3

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