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Clinical role of Bcl-2, Bax, or p53 overexpression in peripheral T-cell lymphomas

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Abstract

Apoptosis pathways are known to be involved in the pathogenesis of peripheral T-cell lymphomas (PTCLs). As such, the current study attempted to investigate the overexpression of Bcl-2, Bax, or p53 with respect to the progression of PTCL. Paraffin-embedded specimens from 74 patients were analyzed immunohistochemically for Bcl-2, Bax, or p53 overexpression including PTCL-unspecified (n=45), extranodal natural killer cell/T-cell lymphoma (n=10), angioimmunoblastic T-cell lymphoma (n=7), anaplastic large cell lymphoma (n=7), and cutaneous T-cell lymphoma (n=5). The Bcl-2 overexpression was exhibited in 33 (45%), Bax, 17 (23%), and p53, 33 patients (45%). Bcl-2 overexpression was strongly associated with advanced stage (p=0.021) and higher international prognostic indices (IPI) (p=0.038). Bcl-2+/p53+ group was found to be associated with advanced stage (p=0.008) and higher IPI (p=0.001), compared with the other groups. The independent expression of Bcl-2 or p53 was not correlated with survival. Meanwhile, when confined to Bcl-2 overexpressing groups, p53 overexpression was significantly associated with poor survival (p=0.05), as the 3-year OS rate was 82.5% for Bcl-2+/p53- cases, yet only 32.9% for Bcl-2+/p53+ cases. Multivariate analyses for OS found the Bcl-2/p53 co-expression (p=0.004) as independent prognostic factor, together with advanced stage (p<0.001) and higher prognostic index for PTCL (p=0.008). Bcl-2 overexpression seemed to correlate with the progression of PTCL interacting with a p53-dependent pathway.

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Authors and Affiliations

  1. Department of Hematology/Oncology, Kyungpook National University Hospital, 50 Samduk 2-Ga, Jung-Gu, 700-412, Daegu, South Korea

    Jin Tae Jung, Dong Hwan Kim, Jong Gwang Kim, Sang Kyun Sohn & Kyu Bo Lee

  2. Department of Pathology, Kyungpook National University Hospital, Daegu, South Korea

    Eun Kyung Kwak & Tae In Park

  3. Department of Hematology/Oncology, School of Medicine, Keimyung University, Daegu, South Korea

    Young Rok Do, Ki Young Kwon & Hong Suk Song

  4. Department of Internal Medicine, Kyungpook National University Hospital, Daegu, South Korea

    Eui Hyun Park

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  1. Jin Tae Jung
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  2. Dong Hwan Kim
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Correspondence to Dong Hwan Kim.

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Jung, J.T., Kim, D.H., Kwak, E.K. et al. Clinical role of Bcl-2, Bax, or p53 overexpression in peripheral T-cell lymphomas. Ann Hematol 85, 575–581 (2006). https://doi.org/10.1007/s00277-006-0127-z

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  • DOI: https://doi.org/10.1007/s00277-006-0127-z

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