Abstract
Purpose: The evaluation of new oily agents for targeting chemoembolization for hepatocellular carcinoma.
Methods: Five types of oily preparation were injected into the hepatic artery of 54 rabbits inoculated with VX2 carcinoma cells in order to evaluate (1) the safety of these preparations, (2) their histologic distribution and the amount of agents remaining at tumor sites, and (3) computed tomographic (CT) images obtained. Of these preparations, three were made by mixing non-iodinated poppy seed oil and a thickener and then adjusted to have a viscosity lower than, equal to, or higher than that of lipiodol. A fourth preparation was a mixture of lipiodol and a thickener with a higher viscosity than lipiodol alone, and the fifth preparation are lipiodol alone.
Results: (1) No injury to the hepatic parenchyma was observed hematologically or histologically. (2) With increase in the viscosity, a significantly larger amount of agent remained at the tumor site. No agent was present at normal sites 14 days after intraarterial injection, regardless of which preparation was given. (3) On CT scans following intraarterial injection, tumor cells were visibly deeply stained in the non-iodinated preparation groups, while the lipiodol groups were not evaluable because of excessively high attenuation.
Conclusion: The non-iodinated oily preparations and highly viscous oily preparations developed in the present study were more useful than lipiodol for treatment of hepatic tumors.
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Konno T, Maeda H, Iwaki K (1984) Selective targeting of anticancer drug and simultaneous image enhancement in solid tumor by arterially administered lipid contrast medium. Cancer 54:2367–2374
Konno T (1990) Targeting cancer chemotherapeutic agents by use of lipiodol contrast medium. Cancer 66:1897–1903
Konno T, Maeda H, Iwaki K (1983) Effect of arterial administration of high-molecular-weight anticancer agent SMANCS with lipid lymphographic agent on hepatoma: A preliminary report. Eur J Cancer Clin Oncol 19:1053–1065
Furuta T, Kanematsu T, Kakizoe S (1988) Selective effect of doxorubicin suspended in lipiodol on VX2 carcinoma in rabbits. J Surg Oncol 39:235–240
Ohsumi M, Koitabashi H, Nagamachi Y, Iijima T (1992) Effect of lipiodol-cisplatinum arterial infusion chemotherapy on cellular immunity. Jpn J Cancer Chemother 19:327–331
Iwai K, Maeda H, Konno T, Matsumura Y, Yamashita R, Yamasaki K, Hirayama S, Miyauti Y (1987) Tumor targeting by arterial administration of lipids: Rabbit model with VX2 carcinoma in the liver. Anticancer Res 7:321–328
Sato M, Kishi K, Shioyama Y, Tsuda M, Terada M, Tanaka H, Nakatani K, Sonomura T, Maeda M, Daimon M, Hamachi J, Kawabata M, Yamada R (1990) Effects of experimental hepatic artery embolization with lipiodol and gelatin sponge on liver tissue. Nippon Act Radiol 50:107–113
Matsuo N, Utida H, Soda S, Ohshima M, Nakano H, Oishi H, Nagano N, Kitamura I, Nishimura Y, Nishimine K, Yoshioka T (1990) Histopathological study of resected specimens after segmental Lp-TAE using lipiodol mixed with anticancer agent for hepatocellular carcinoma: Anti-tumor effect and influence on non-tumor area. Acta Hepatol Japon 31:1084–1093
Konno T (1992) Targeting chemotherapy for hepatoma: Arterial administration of anticancer drugs dissolved in lipiodol. Eur J Cancer 28:403–409
Nakamura H, Hashimoto T, Taguchi T, Oi H, Inoue K, Seki K, Mizumoto S, Tsukaguti I, Arai Y, Sawada S (1987) Oily chemoembolization of hepatoma. Jpn J Cancer Chemother 14:381–387
Segawa T, Izawa K, Tokunaga S, Ura K, Matsumoto T, Eto T, Motoshima K, Tsunoda T, Tsuchiya R (1991) Evaluation of preoperative CT findings after transcatheter arterial embolization using lipiodol in hepatocellular carcinoma. Jpn J Gastroenterol Surg 24:51–58
Koganemaru F, Okazaki M, Higashihara H, Higuchi T (1990) The evaluation of the effect of embolization using lipiodol for hepatocellular carcinoma in 59 resected cases. Diagn Imaging Abdomen 10:595–602
Yoshioka H, Nakagawa K, Shindou H, Ono Y, Kawakami A, Mabuchin N, Arita S, Fujii K, Yoshida A, Hamada T, Ishida O (1989) MR imaging of hepatocellular carcinoma following transcatheter hepatic chemo-embolization. Nippon Act Radiol 49:119–127
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Hamuro, M., Nakamura, K., Sakai, Y. et al. New oily agents for targeting chemoembolization for hepatocellular carcinoma. Cardiovasc Intervent Radiol 22, 130–134 (1999). https://doi.org/10.1007/s002709900348
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DOI: https://doi.org/10.1007/s002709900348