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In Vivo Evaluation of Lung Microwave Ablation in a Porcine Tumor Mimic Model

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Abstract

Purpose

To evaluate the microwave ablation of created tumor mimics in the lung of a large animal model (pigs), with examination of the ablative synergy of multiple antennas.

Methods

Fifty-six tumor-mimic models of various sizes were created in 15 pigs by using barium-enriched minced collected thigh muscle injected into the lung of the same animal. Tumors were ablated under fluoroscopic guidance by single-antenna and multiple-antenna microwaves.

Results

Thirty-five tumor models were treated in 11 pigs with a single antenna at 75 W for 15 min, with 15 measuring 20 mm in diameter, 10 measuring 30 mm, and 10 measuring 40 mm. Mean circularity of the single-antenna ablation zones measured 0.64 ± 0.12, with a diameter of 35.7 ± 8.7 mm along the axis of the antenna and 32.7 ± 12.8 mm perpendicular to the feeding point. Multiple-antenna delivery of 75 W for 15 min caused intraprocedural death of 2 animals; modified protocol to 60 W for 10 min resulted in an ablation zone with a diameter of 43.0 ± 7.7 along the axis of the antenna and 54.8 ± 8.5 mm perpendicular to the feeding point; circularity was 0.70 ± 0.10

Conclusions

A single microwave antenna can create ablation zones large enough to cover lung tumor mimic models of ≤4 cm with no heat sink effect from vessels of ≤6 mm. Synergic use of 3 antennas allows ablation of larger volumes than single-antenna or radiofrequency ablation, but great caution must be taken when 3 antennas are used simultaneously in the lung in clinical practice.

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Acknowledgments

Animals, microwave generators, and antennas were supplied by Hospital Service Spa, Aprilia, Italy. No salary or fees were paid to any investigator.

Conflict of interest

The authors declare that they have no conflict of interest.

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Authors and Affiliations

  1. Service Radiologie Cardiovasculaire et Interventionnelle, Centre Chirurgical Marie Lannelongue, 133 Avenue de la Résistance, 92350, Le Plessis Robinson, France

    Olivier Planché

  2. Service de Radiologie Interventionnelle, Institut Gustave Roussy, 114 rue Edouard Vaillant, 94805, Villejuif, France

    Christophe Teriitehau, Sana Boudabous, Joey Marie Robinson, Pramod Rao, Frederic Deschamps, Geoffroy Farouil & Thierry de Baere

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  1. Olivier Planché
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  2. Christophe Teriitehau
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  8. Thierry de Baere
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Correspondence to Olivier Planché.

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Planché, O., Teriitehau, C., Boudabous, S. et al. In Vivo Evaluation of Lung Microwave Ablation in a Porcine Tumor Mimic Model. Cardiovasc Intervent Radiol 36, 221–228 (2013). https://doi.org/10.1007/s00270-012-0399-8

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  • DOI: https://doi.org/10.1007/s00270-012-0399-8

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