Abstract
We report the case of a 48-year-old woman presenting with recurrent uterine leiomyosarcoma (LMS) associated with right iliac vein and inferior vena cava (IVC) invasion and left lower lobe pulmonary tumor embolus. Because the prognosis and treatment differ from that of thrombotic pulmonary emboli, the differentiating imaging characteristics of intravascular tumor embolism are reviewed. To our knowledge, only two other cases of intravenous uterine leiomyosarcomatosis have been described in the existing literature, and this is the first reported case of the entity with associated intravascular tumor embolism.
Similar content being viewed by others
References
Harlow BL, Weiss NS, Lofton S (1986) The epidemiology of sarcomas of the uterus. J Natl Cancer Inst 76:399–402
Coard KC, Fletcher HM (2002) Leiomyosarcoma of the uterus with a florid intravascular component (“intravenous leiomyosarcomatosis”). Int J Gynecol Pathol 21:182–185
Moorjani N, Kuo J, Ashley S, Hughes G (2005) Intravenous uterine leiomyosarcomatosis with intracardial extension. J Card Surg 20:382–385
Stein PD, Beemath A, Meyers FA, Skaf E, Sanchez J, Olson RE (2006) Incidence of venous thromboembolism in patients hospitalized with cancer. Am J Med 119:60–68
Hatcher PA, Anderson EE, Paulson DF, Carson CC, Robertson JE (1991) Surgical management and prognosis of renal cell carcinoma invading the vena cava. J Urol 145:20–23
Svane S (1969) Tumor thrombus of the inferior vena cava resulting from renal carcinoma: A report on 12 autopsied cases. Scand J Urol Nephrol 3:245–256
Norris HJ, Parmley T (1975) Mesenchymal tumors of the uterus. V. Intravenous leiomyomatosis. A clinical and pathologic study of 14 cases. Cancer 36:2164–2178
Livi L, Paiar F, Shah N, Blake P, Villanucci A, Amunni G, Barca R, Judson I, Lodge N, Meldolesi E, Simontacchi G, Piperno G, Galardi A, Scoccianti S, Biti GP, Harmer C (2003) Uterine sarcoma: Twenty-seven years of experience. Int J Radiat Oncol Biol Phys 57:1366–1373
Burns B, Curry RH, Bell ME (1979) Morphologic features of prognostic significance in uterine smooth muscle tumors: A review of eighty-four cases. Am J Obstet Gynecol 135:109–114
Ahmed M, Zangos S, Bechstein WO, Vogl TJ (2004) Intravenous leiomyomatosis. Eur Radiol 14:1316–1317
Goldhaber SZ, Dricker E, Buring JE, Eberlein K, Godleski JJ, Mayer RJ, Hennekens CH (1987) Clinical suspicion of autopsy-proven thrombotic and tumor pulmonary embolism in cancer patients. Am Heart J 114:1432–1435
Kane RD, Hawkins HK, Miller JA, Noce PS (1975) Microscopic pulmonary tumor emboli associated with dyspnea. Cancer 36:1473–1482
Winterbauer RH, Elfenbein IB, Ball WC Jr (1968) Incidence and clinical significance of tumor embolization to the lungs. Am J Med 45:271–290
Chakeres DW, Spiegel PK (1982) Fatal pulmonary hypertension secondary to intravascular metastatic tumor emboli. AJR Am J Roentgenol 139:997–1000
Crane R, Rudd TG, Dail D (1984) Tumor microembolism: pulmonary perfusion pattern. J Nucl Med 25:877–880
Fanta CH, Compton CC (1980) Microscopic tumour emboli to the lungs: A hidden cause of dyspnoea and pulmonary hypertension. Thorax 35:794–795
Shepard JA, Moore EH, Templeton PA, McLoud TC (1993) Pulmonary intravascular tumor emboli: Dilated and beaded peripheral pulmonary arteries at CT. Radiology 187:797–801
Author information
Authors and Affiliations
Corresponding author
Rights and permissions
About this article
Cite this article
McDonald, D.K., Kalva, S.P., Fan, CM. et al. Leiomyosarcoma of the Uterus with Intravascular Tumor Extension and Pulmonary Tumor Embolism. Cardiovasc Intervent Radiol 30, 140–142 (2007). https://doi.org/10.1007/s00270-006-0118-4
Published:
Issue Date:
DOI: https://doi.org/10.1007/s00270-006-0118-4