Skip to main content
SpringerLink
Log in

Rheological Changes After Stenting of a Cerebral Aneurysm: A Finite Element Modeling Approach

  • LABORATORY INVESTIGATION
  • Published:
CardioVascular and Interventional Radiology Aims and scope Submit manuscript

Abstract

Hemodynamic changes in intracranial aneurysms after stent placement include the appearance of areas with stagnant flow and low shear rates. We investigated the influence of stent placement on blood flow velocity and wall shear stress of an intracranial aneurysm using a finite element modeling approach. To assess viscosity changes induced by stent placement, the rheology of blood as non-Newtonian fluid was taken into account in this model. A two-dimensional model with a parent artery, a smaller branching artery, and an aneurysm located at the bifurcation, before and after stent placement, was used for simulation. Flow velocity plots and wall shear stress before and after stent placement was calculated over the entire cardiac circle. Values for dynamic viscosity were calculated with a constitutive equation that was based on experimental studies and yielded a viscosity, which decreases as the shear rate increases. Stent placement lowered peak velocities in the main vortex of the aneurysm by a factor of at least 4 compared to peak velocities in the main artery, and it considerably decreased the wall shear stress of the aneurysm. Dynamic viscosity increases after stent placement persisted over a major part of the cardiac cycle, with a factor of up to 10, most pronounced near the dome of the aneurysm. Finite element modeling can offer insight into rheological changes induced by stent treatment of aneurysms and allows visualizing dynamic viscosity changes induced by stent placement.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Figure 1
Figure 2
Figure 3
Figure 4
Figure 5

Similar content being viewed by others

References

  1. Lanzino G, Wakhloo AK, Fessler RD, et al. (1999) Efficacy and current limitations of intravascular stents for intracranial internal carotid, vertebral, and basilar artery aneurysms. J Neurosurg 91:538–546

    PubMed  Google Scholar 

  2. Lylyk P, Cohen JE, Ceratto R, et al. (2001) Combined endovascular treatment of dissecting vertebral artery aneurysms by using stents and coils. J Neurosurg 94:427–432

    PubMed  Google Scholar 

  3. Geremia G, Haklin M, Brennecke L (1994) Embolization of experimentally created aneurysms with intravascular stent devices. Am J Neuroradiol 15:1223–1231

    PubMed  Google Scholar 

  4. Wakhloo AK, Tio FO, Lieber BB, et al. (1995) Self-expanding nitinol stents in canine vertebral arteries: hemodynamics and tissue response. Am J Neuroradiol 16:1043–1051

    PubMed  Google Scholar 

  5. Sadasivan C, Lieber BB, Gounis MJ, et al. (2002) Angiographic quantification of contrast medium washout from cerebral aneurysms after stent placement. Am J Neuroradiol 23:1214–1221

    PubMed  Google Scholar 

  6. Vanninen R, Manninen H, Ronkainen A (2003) Broad-based intracranial aneurysms: thrombosis induced by stent placement. Am J Neuroradiol 24:263–266

    PubMed  Google Scholar 

  7. Foutrakis GN, Yonas H, Sclabassi RJ. (1997) Finite element methods in the simulation and analysis of intracranial blood flow. Neurol Res 19:174–186

    PubMed  Google Scholar 

  8. Burleson AC, Strother CM, Turitto VT (1995) Computer modeling of intracranial saccular and lateral aneurysms for the study of their hemodynamics. Neurosurgery 37:774–782; discussion 782–774

    PubMed  Google Scholar 

  9. Aenis M, Stancampiano AP, Wakhloo AK, et al. (1997) Modeling of flow in a straight stented and nonstented side wall aneurysm model. J Biomech Eng 119:206–212

    PubMed  Google Scholar 

  10. Steinman DA, Milner JS, Norley CJ, et al. (2003) Image-based computational simulation of flow dynamics in a giant intracranial aneurysm. Am J Neuroradiol 24:559–566

    PubMed  Google Scholar 

  11. Foutrakis GN, Yonas H, Sclabassi RJ (1999) Saccular aneurysm formation in curved and bifurcating arteries. Am J Neuroradiol 20:1309–1317

    PubMed  Google Scholar 

  12. Scott S, Ferguson GG, Roach MR (1972) Comparison of the elastic properties of human intracranial arteries and aneurysms. Can J Physiol Pharmacol 50:328–332

    PubMed  Google Scholar 

  13. Canham PB, Ferguson GG (1985) A mathematical model for the mechanics of saccular aneurysms. Neurosurgery 17:291–295

    PubMed  Google Scholar 

  14. Steiger HJ, Aaslid R, Keller S, et al. (1989) Strength, elasticity and viscoelastic properties of cerebral aneurysms. Heart Vessels 5:41–46

    Article  PubMed  Google Scholar 

  15. Hayashi K, Handa H, Nagasawa S, et al. (1980) Stiffness and elastic behavior of human intracranial and extracranial arteries. J Biomech 13:175–184

    Article  PubMed  Google Scholar 

  16. Jackson SP, Nesbitt WS, Kulkarni S (2003) Signaling events underlying thrombus formation. J Thromb Haemost 1:1602–1612

    Article  PubMed  Google Scholar 

  17. Hirabayashi M, Ohta M, Rufenacht DA, et al. (2003) Characterization of flow reduction properties in an aneurysm due to a stent. Phys Rev E Stat Nonlin Soft Matter Phys 68:1–6

    Google Scholar 

  18. McMillan DE, Strigberger J, Utterback NG (1987) Rapidly recovered transient flow resistance: a newly discovered property of blood. Am J Physiol 253:H919–H926

    PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Divsion of Neuroradiology, Department of Radiology, University Hospital of Geneva, Geneva, Switzerland

    Makoto Ohta, Stephan G. Wetzel, Karl O. Lovblad, Hasan Yilmaz & Daniel A. Rüfenacht

  2. Divsion of Neuroradiology, Department of Radiology, University Hospital of Basel, Basel, Switzerland

    Stephan G. Wetzel

  3. Laboratoire de Biorheologie et d’Hydrodynamique Physicochimique, Université Paris 7, Paris, France

    Philippe Dantan, Caroline Bachelet & Patrice Flaud

Authors
  1. Makoto Ohta
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Stephan G. Wetzel
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Philippe Dantan
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Caroline Bachelet
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Karl O. Lovblad
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. Hasan Yilmaz
    View author publications

    You can also search for this author in PubMed Google Scholar

  7. Patrice Flaud
    View author publications

    You can also search for this author in PubMed Google Scholar

  8. Daniel A. Rüfenacht
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Stephan G. Wetzel.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Ohta, M., Wetzel, S.G., Dantan, P. et al. Rheological Changes After Stenting of a Cerebral Aneurysm: A Finite Element Modeling Approach. Cardiovasc Intervent Radiol 28, 768–772 (2005). https://doi.org/10.1007/s00270-004-7148-6

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s00270-004-7148-6

Keywords

Search

Navigation