Abstract
Purpose
To evaluate the safety and efficacy of a porcine-derived gelfoam, Curaspon, for the temporary occlusion of the visceral arteries.
Methods
Curaspon was used for the selective embolization of segmentary hepatic, unilateral polar renal, and single lumbar arteries of 10 pigs under general anesthesia. Sequential angiographic checks were carried out and the pigs killed between 3 days and 2 weeks later. Macroscopic and microscopic studies using standard techniques were used to evaluate the immediate efficacy of embolization, duration of and completeness of recanalization on angiography, macroscopic appearance of target-organ ischemia, and microscopic analysis of inflammatory reaction.
Results
Immediate arterial occlusion was obtained in all cases. Renal arteries showed a total recanalization in 63% of cases on day 7 and 100% on day 14. Total hepatic recanalization was obtained in 100% of animals on day 7. All lumbar arteries were recanalized on day 14. Microscopic analysis in the kidney revealed a mild inflammatory reaction and a progressive lysis of the Curaspon (87% of samples at day 3 showed a persistence of Curaspon and 5% at day 14). In some cases, localized and partial destruction of the arterial wall was visualized. In the liver the same patterns were observed but resolved more completely and more rapidly.
Conclusions
Curaspon is an efficient material for the temporary occlusion of visceral and parietal arteries in pigs. However, arterial aneurysms were observed and a relationship of these with the material cannot be excluded.
Similar content being viewed by others
References
Rösch J, Dotter CT, Brown MJ (1972) Selective arterial embolization: A new method for control of acute gastrointestinal bleeding. Radiology 102:303–306
Gold RE, Grace M (1975) Gelfoam embolization of the left gastric artery for bleeding ulcer. Radiology 116:575–580
Sato M, Yamada R, Uchida B, Hedgepeth P, Rosch J (1993) Effect of hepatic artery embolization with Lipiodol and gelatin sponge particles on normal swine liver. Cardiovasc Intervent Radiol 16:348–354
Yamashita Y, Takahashi M, Fukushima S, Nishida M, Nakano M (1987) Experimental study of hepatic artery embolization: Evaluation of various embolic materials. Radiat Med 5:75–82
Vlahos BL, Karatzas G, Papaharalambous N, Pontifex GR (1980) Percutaneous arterial embolization in the kidneys of dogs: A comparative study of eight different materials. Br J Radiol 53:289–298
Jander HP, Russinovich NA (1980) Transcatheter gelfoam embolization in abdominal, retroperitoneal, and pelvic hemorrhage. Radiology 136:337–344
Sniderman KW, Sos TA, Alonso DR (1981) Transcatheter embolization with Gelfoam and Avitene: The effect of Sotradecol on the duration of arterial occlusion. Invest Radiol 16:501–507
Phadke RV, Sawlani V, Rastogi H, et al (1997) Iatrogenic renal vascular injuries and their radiological management. Clin Radiol 52:119–123
Fisher RG, Ben-Menachem Y, Whigham C (1989) Stab wounds of the renal artery branches: Angiographic diagnosis and treatment by embolization. AJR Am J Roentgenol 152:1231–1235
Ansell JE, Widrich WC, Johnson WC, Maizels M, Robbins AH (1978) Gelfoam and autologous clot embolization: Effect on coagulation. Invest Radiol 13:115–120
Berenstein A, Russel E (1981) Gelatin Sponge in therapeutic neuroradiology: A subject review. Radiology 141:105–112
CEE 86/609. Official Journal of the EEC 18/102/1986; L 358:1–28
Cylwik B, Darewicz J, Karasewicz B (1985) Histological and histochemical changes in the dog kidney after renal artery embolization with spongostan. Int Urol Nephrol 17:203–210
Cylwik B, Darewicz J, Karasewicz B (1985) Morphometric investigations of dog kidney infarcts after embolization of the renal artery with spongostan. Int Urol Nephrol 17:109–114
Han YM, Lee JM, Jin KY, Lee SY, Kim CS (1999) Embolization of superior mesenteric artery branches in dogs: Ischemic bowel changes depend on location of vessel occlusion and embolic materials. Invest Radiology 34:629–635
Kaufman SL, Straudberg JD, Bartsh KH, White RI Jr (1978) Transcatheter embolization with microfibrillar collagen in swine. Invest Radiol 13:200–204
Sonomura T, Yamada R, Kishi K, Nichida N, Yang RJ, Sato M (1997) Cardiovasc Intervent. Radiol 20:50–53
Acknowledgement
This study was partially supported by Caps Recherche.
Author information
Authors and Affiliations
Corresponding author
Rights and permissions
About this article
Cite this article
Louail, B., Sapoval, M., Bonneau, M. et al. A New Porcine Sponge Material for Temporary Embolization: An Experimental Short-Term Pilot Study in Swine. Cardiovasc Intervent Radiol 29, 826–831 (2006). https://doi.org/10.1007/s00270-004-0299-7
Published:
Issue Date:
DOI: https://doi.org/10.1007/s00270-004-0299-7