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Transcatheter Arterial Chemoembolization of Liver Tumors: Effects of Embolization Protocol on Injectable Volume of Chemotherapy and Subsequent Arterial Patency

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Abstract

The purpose of this study was to determine whether transcatheter arterial chemoembolization (TACE) protocol affects the total volume of chemotherapy injected into the liver as well as subsequent arterial patency. A total of 160 patients with primary or secondary liver cancer were treated with 3 different chemoembolization protocols at a single institution. Data were analyzed retrospectively. Group 1 (n = 36) consisted of slurry of chemotherapy, oil and polyvinyl alcohol particles (PVA), group 2 (n = 91), chemotherapy and oil followed by PVA, and group 3 (n = 33), chemotherapy and oil followed by Gelfoam pledgets. The total volume of chemotherapy injected into the liver was recorded. Arterial patency was determined during subsequent chemoembolizations. The mean percentage of total intended chemotherapy dose administered was 54.6% for group 1, 75.3% for group 2, and 80.6% for group 3. Arterial patency at follow-up angiography was 56% for group 1, 74% for group 2, and 81% for group 3. The slurry protocol (group 1) significantly reduced arterial patency and injectable volume of chemotherapy during TACE.

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Acknowledgements

This study was presented in part at the Annual Meeting of the Cardiovascular and Interventional Radiology Society of Europe, in Prague, Czech Republic, from September 26–30, 1999 and at the Annual Scientific Meeting of the Society for Cardiovascular and Interventional Radiology in Baltimore, Maryland from April 6–11, 2002. JFG was supported by an American Cancer Society research grant (58-005-39).

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Authors and Affiliations

  1. The Russell H. Morgan Department of Radiology, The Johns Hopkins University School of Medicine, 600 North Wolfe Street, Baltimore, Maryland 21287, USA

    Jean-Francois H. Geschwind, Douglas E. Ramsey, Hicham Kobeiter & Krishna Juluru

  2. The Russell H. Morgan Department of Surgery, The Johns Hopkins University School of Medicine, 600 North Wolfe Street, Baltimore, Maryland 21287, USA

    Jean-Francois H. Geschwind & Michael A. Choti

  3. Department of Surgery, Erasmus University Hospital, Rotterdam, The Netherlands

    B.C.H. van der Wal

  4. Department of Cardiovascular and Interventional Radiology, Baystate Medical Center, 759 Chestnut Street, Springfield, Massachusetts 01199, USA

    George G. Hartnell

Authors
  1. Jean-Francois H. Geschwind
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  2. Douglas E. Ramsey
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  3. B.C.H. van der Wal
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  4. Hicham Kobeiter
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  5. Krishna Juluru
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  7. Michael A. Choti
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Geschwind, JF., Ramsey, D., van der Wal, B. et al. Transcatheter Arterial Chemoembolization of Liver Tumors: Effects of Embolization Protocol on Injectable Volume of Chemotherapy and Subsequent Arterial Patency . CVIR 26, 111–117 (2003). https://doi.org/10.1007/s00270-002-2524-6

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