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Double Role of HLA in Organ Transplantation

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Abstract.

Although HLA matching can improve organ graft survival, well matched grafts fail and poorly matched ones survive. Recently evidence has been found that perinatal exposure to noninherited antigens (NIMAs) has a lifelong impact on the immune repertoire of the individual. The state of the art of the influence of NIMAs on graft survival is summarized. These findings could lead to a better understanding of the allograft reaction.

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  1. Europdonor Foundation, Leiden University Medical Centre, Building 1, E3-Q, Albinusdreef 2, 2333 ZA Leiden, P.O. Box 9600, 2300 RC Leiden, The Netherlands, NL

    Jon J. van Rood

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  1. Jon J. van Rood
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van Rood, J. Double Role of HLA in Organ Transplantation. World J. Surg. 24, 823–827 (2000). https://doi.org/10.1007/s002680010132

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  • DOI: https://doi.org/10.1007/s002680010132

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