Abstract
Background
Large (≥3 cm) benign thyroid nodules usually cause clinical symptoms or cosmetic concerns and therefore require treatment. Microwave ablation (MWA) is a potential valid non-surgical treatment alternative, but there is a lack of evidence. Thus, this study is to evaluate the safety and efficacy of MWA in the treatment of large benign thyroid nodules.
Methods
A retrospective study was conducted on 42 large benign thyroid nodules in 40 patients treated with MWA. We used the trans-isthmic approach and moving-shot technique to perform the procedure under ultrasound (US) guidance. Patients were followed by clinical and US examinations at 1, 3, 6, and 12 months after the MWA. Study outcomes were complications, volume reduction ratio (VRR), symptom and cosmetic scores, and the requirement of multiple MWA sessions.
Results
There were 31 females and 9 males, with a median age of 46 years. The medians of largest diameter and volume of the nodules were 40 mm and 22 ml. Four (10%) minor complications were observed. The mean VRR was 75.1, 85.2, and 96.4% after 3, 6, and 12 months. The mean symptom and cosmetic scores dropped from 8.0 and 3.8 (before treatment) to 2.8 and 2.3 (at 12 months), respectively. Thirteen nodules (31%) required two MWA sessions.
Conclusions
MWA is safe, effective, and can be a good option to treat large benign thyroid nodules. More studies with large dataset and long follow-up are required to improve its safety and efficacy.
Similar content being viewed by others
References
Gharib H, Papini E, Paschke R et al (2010) American Association of Clinical Endocrinologists, Associazione Medici Endocrinologi, and European Thyroid Association medical guidelines for clinical practice for the diagnosis and management of thyroid nodules. J Endocrinol Invest 33:1–50
Hegedus L (2004) Clinical practice. The thyroid nodule. N Engl J Med 351:1764–1771
Arora N, Scognamiglio T, Zhu B et al (2008) Do benign thyroid nodules have malignant potential? An evidence-based review. World J Surg 32:1237–1246. https://doi.org/10.1007/s00268-008-9484-1
Haugen BR, Alexander EK, Bible KC et al (2016) 2015 American Thyroid Association management guidelines for adult patients with thyroid nodules and differentiated thyroid cancer: The American Thyroid Association guidelines task force on thyroid nodules and differentiated thyroid cancer. Thyroid 26:1–133
Bandeira-Echtler E, Bergerhoff K, Richter B (2014) Levothyroxine or minimally invasive therapies for benign thyroid nodules. Cochrane Database Syst Rev 6:CD00409898
Mainini AP, Monaco C, Pescatori LC et al (2017) Image-guided thermal ablation of benign thyroid nodules. J Ultrasound 20:11–22
Che Y, Jin S, Shi C et al (2015) Treatment of benign thyroid nodules: comparison of surgery with radiofrequency ablation. AJNR Am J Neuroradiol 36:1321–1325
Yue WW, Wang SR, Li XL et al (2016) Quality of life and cost-effectiveness of radiofrequency ablation versus open surgery for benign thyroid nodules: a retrospective cohort study. Sci Rep 6:37838
Baek JH, Kim YS, Lee D et al (2010) Benign predominantly solid thyroid nodules: prospective study of efficacy of sonographically guided radiofrequency ablation versus control condition. AJR Am J Roentgenol 194:1137–1142
Baek JH, Moon WJ, Kim YS et al (2009) Radiofrequency ablation for the treatment of autonomously functioning thyroid nodules. World J Surg 33:1971–1977. https://doi.org/10.1007/s00268-009-0130-3
Ahmed M, Solbiati L, Brace CL et al (2014) Image-guided tumor ablation: standardization of terminology and reporting criteria—a 10-year update. Radiology 273:241–260
Cheng Z, Che Y, Yu S et al (2017) US-guided percutaneous radiofrequency versus microwave ablation for benign thyroid nodules: a prospective multicenter study. Sci Rep 7:9554
Heck K, Happel C, Grunwald F et al (2015) Percutaneous microwave ablation of thyroid nodules: effects on thyroid function and antibodies. Int J Hyperth 31:560–567
Jin H, Fan J, Liao K et al (2018) A propensity score matching study between ultrasound-guided percutaneous microwave ablation and conventional thyroidectomy for benign thyroid nodules treatment. Int J Hyperth 35:232–238
Korkusuz H, Nimsdorf F, Happel C et al (2015) Percutaneous microwave ablation of benign thyroid nodules. Functional imaging in comparison to nodular volume reduction at a 3-month follow-up. Nuklearmedizin 54:13–19
Korkusuz Y, Kohlhase K, Groner D et al (2016) Microwave ablation of symptomatic benign thyroid nodules: energy requirement per ml volume reduction. RoFo:Fortschritte auf dem Gebiete der Rontgenstrahlen und der Nuklearmedizin 188:1054–1060
Liu YJ, Qian LX, Liu D et al (2017) Ultrasound-guided microwave ablation in the treatment of benign thyroid nodules in 435 patients. Exp biol Med (Maywood, NJ) 242:1515–1523
Vorlander C, David Kohlhase K, Korkusuz Y et al (2018) Comparison between microwave ablation and bipolar radiofrequency ablation in benign thyroid nodules: differences in energy transmission, duration of application and applied shots. Int J Hyperth 35:216–225
Wang B, Han ZY, Yu J et al (2017) Factors related to recurrence of the benign non-functioning thyroid nodules after percutaneous microwave ablation. Int J Hyperth 33:459–464
Wei Y, Qian L, Liu JB et al (2018) Sonographic measurement of thyroid nodule changes after microwave ablation: relationship between multiple parameters. Int J Hyperth 34:660–668
Wu W, Gong X, Zhou Q et al (2017) Ultrasound-guided percutaneous microwave ablation for solid benign thyroid nodules: comparison of MWA versus control group. Int J Endocrinol 2017:9724090
Wu W, Gong X, Zhou Q et al (2017) US-guided percutaneous microwave ablation for the treatment of benign thyroid nodules. Endocr J 64:1079–1085
Yue W, Wang S, Wang B et al (2013) Ultrasound guided percutaneous microwave ablation of benign thyroid nodules: safety and imaging follow-up in 222 patients. Eur J Radiol 82:e11–e16
Yue WW, Wang SR, Lu F et al (2017) Radiofrequency ablation vs. microwave ablation for patients with benign thyroid nodules: a propensity score matching study. Endocrine 55:485–495
Chung SR, Suh CH, Baek JH et al (2017) Safety of radiofrequency ablation of benign thyroid nodules and recurrent thyroid cancers: a systematic review and meta-analysis. Int J Hyperth 33:920–930
Zheng BW, Wang JF, Ju JX et al (2018) Efficacy and safety of cooled and uncooled microwave ablation for the treatment of benign thyroid nodules: a systematic review and meta-analysis. Endocrine 62:307–317
Cesareo R, Naciu AM, Iozzino M et al (2018) Nodule size as predictive factor of efficacy of radiofrequency ablation in treating autonomously functioning thyroid nodules. Int J hyperth 34:617–623
Deandrea M, Garino F, Alberto M et al (2019) Radiofrequency ablation for benign thyroid nodules according to different ultrasound features: an Italian multicentre prospective study. Eur J Endocrinol 180:79–87
Dobnig H, Amrein K (2018) Monopolar radiofrequency ablation of thyroid nodules: a prospective Austrian single-center study. Thyroid 28:472–480
Jung SL, Baek JH, Lee JH et al (2018) Efficacy and safety of radiofrequency ablation for benign thyroid nodules: a prospective multicenter study. Korean J Radiol 19:167–174
Vuong NL, Dinh LQ, Bang HT et al (2019) Radiofrequency ablation for benign thyroid nodules: 1-year follow-up in 184 patients. World J Surg 43:2447–2453. https://doi.org/10.1007/s00268-019-05044-5
Acknowledgements
None.
Funding
This study has no funding.
Author information
Authors and Affiliations
Corresponding author
Ethics declarations
Conflicts of interest
The authors declare that they have no conflict of interest.
Additional information
Publisher's Note
Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.
Rights and permissions
About this article
Cite this article
Khanh, H.Q., Hung, N.Q., Vinh, V.H. et al. Efficacy of Microwave Ablation in the Treatment of Large (≥3 cm) Benign Thyroid Nodules. World J Surg 44, 2272–2279 (2020). https://doi.org/10.1007/s00268-020-05432-2
Published:
Issue Date:
DOI: https://doi.org/10.1007/s00268-020-05432-2