Abstract
Background
The exact role of IV contrast-enhanced computed tomography (CT) in the diagnosis of necrotizing soft tissue infections (NSTIs) has not yet been established. We aimed to explore the role of CT in patients with clinical suspicion of NSTI and assess its sensitivity and specificity for NSTI.
Methods
The medical records of patients admitted between 2009 and 2016, who received IV contrast-enhanced CT to rule out NSTI, were reviewed. CT was considered positive in case of: (a) gas in soft tissues, (b) multiple fluid collections, (c) absence or heterogeneity of tissue enhancement by the IV contrast, and (d) significant inflammatory changes under the fascia. NSTI was confirmed only by the presence of necrotic tissue during surgical exploration. NSTI was considered absent if surgical exploration failed to identify necrosis, or if the patient was successfully treated non-operatively.
Results
Of the 184 patients, 17 had a positive CT and hence underwent surgical exploration with NSTI being confirmed in 13 of them (76%). Of the 167 patients that had a negative CT, 38 (23%) underwent surgical exploration due to the high clinical suspicion for NSTI and were all found to have non-necrotizing infections; the remaining 129 (77%) were managed non-operatively with successful resolution of symptoms. The sensitivity of CT in identifying NSTI was 100%, the specificity 98%, the positive predictive value 76%, and the negative predictive value 100%.
Conclusions
A negative IV contrast-enhanced CT scan can reliably rule out the need for surgical intervention in patients with initial suspicion of NSTI.
Similar content being viewed by others
References
Anaya DA, Dellinger EP (2007) Necrotizing soft-tissue infection: diagnosis and management. Clin Infect Dis 44:705–710
Hussein QA, Anaya DA (2013) Necrotizing soft tissue infections. Crit Care Clin 29:795–806
De Waele JJ (2012) Management of necrotizing skin and soft tissue infections. Expert Rev Anti Infect Ther 10:805–814
Hakkarainen TW, Kopari NM, Pham TN et al (2014) Necrotizing soft tissue infections: review and current concepts in treatment, systems of care, and outcomes. Curr Probl Surg 51:344–362
Zacharias N, Velmahos GC, Salama A et al (2010) Diagnosis of necrotizing soft tissue infections by computed tomography. Arch Surg 145:452–455
Struk DW, Munk PL, Lee MJ et al (2001) Imaging of soft tissue infections. Radiol Clin North Am 39:277–303
Wong CH, Khin LW, Heng KS et al (2004) The LRINEC (Laboratory Risk Indicator for Necrotizing Fasciitis) score: a tool for distinguishing necrotizing fasciitis from other soft tissue infections. Crit Care Med 32:1535–1541
Arslan A, Pierre-Jerome C, Borthne A (2000) Necrotizing fasciitis: unreliable MRI findings in the preoperative diagnosis. Eur J Radiol 36:139–143
Wysoki MG, Santora TA, Shah RM et al (1997) Necrotizing fasciitis: CT characteristics. Radiology 203:859–863
Becker M, Zbären P, Hermans R et al (1997) Necrotizing fasciitis of the head and neck: role of CT in diagnosis and management. Radiology 202:471–476
Fisher JR, Conway MJ, Takeshita RT et al (1979) Necrotizing fasciitis. Importance of roentgenographic studies for soft-tissue gas. JAMA 241:803–806
Fayad LM, Carrino JA, Fishman EK (2007) Musculoskeletal infection: role of CT in the emergency department. Radiographics 27:1723–1736
Holland MJ (2009) Application of the Laboratory Risk Indicator in Necrotising Fasciitis (LRINEC) score to patients in a tropical tertiary referral centre. Anaesth Intensive Care 37:588–592
Burner E, Henderson SO, Burke G et al (2016) Inadequate sensitivity of laboratory risk indicator to rule out necrotizing fasciitis in the emergency department. West J Emerg Med 17:333–336
McGillicuddy EA, Lischuk AW, Schuster KM et al (2011) Development of a computed tomography-based scoring system for necrotizing soft-tissue infections. J Trauma 70:894–899
Funding
This research did not receive any specific grant from funding agencies in the public, commercial, or not-for-profit sectors.
Author information
Authors and Affiliations
Corresponding author
Ethics declarations
Conflict of interest
The authors declare that they have no conflict of interest.
Rights and permissions
About this article
Cite this article
Martinez, M., Peponis, T., Hage, A. et al. The Role of Computed Tomography in the Diagnosis of Necrotizing Soft Tissue Infections. World J Surg 42, 82–87 (2018). https://doi.org/10.1007/s00268-017-4145-x
Published:
Issue Date:
DOI: https://doi.org/10.1007/s00268-017-4145-x