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Sphincter-Preserving Surgery for Low Rectal Cancers: Incidence and Risk Factors for Permanent Stoma

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Abstract

Background

Advances in surgical techniques and paradigm changes in rectal cancer treatment have led to a drastic decline in the abdominoperineal resection rate, and sphincter-preserving operation is possible in distal rectal cancer.

Objective

The aim of this study is to evaluate the long-term incidence of permanent stoma after sphincter-preserving surgery for low rectal cancer and its corresponding risk factors.

Method

From 2000 to 2014, patients who underwent sphincter-preserving low anterior resection for low rectal cancer (within 5 cm from the anal verge) were included. The occurrence of permanent stoma over time and its risk factors were investigated by using a Cox proportional hazards regression model.

Results

This study included 194 patients who underwent ultra-low anterior resection for distal rectal cancer, and the median follow-up period was 77 months for the surviving patients. Forty-six (23.7%) patients required a permanent stoma eventfully. Anastomotic-related complications and disease progression were the main reasons for permanent stoma. Clinical anastomotic leakage (HR 5.72; 95% CI 2.31–14.12; p < 0.001) and neoadjuvant chemoradiation (HR 2.34; 95% CI 1.12–4.90; p = 0.024) were predictors for permanent primary stoma. Local recurrence (HR 16.09; 95% CI 5.88–44.03; p < 0.001) and T4 disease (HR 11.28; 95% CI 2.99–42.49; p < 0.001) were predictors for permanent secondary stoma. The 5- and 10-year cumulative incidence for permanent stoma was 24.1 and 28.0%, respectively.

Conclusion

Advanced disease, prior chemoradiation, anastomotic leakage and local recurrence predispose patients to permanent stoma should be taken into consideration when contemplating sphincter-preserving surgery.

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Authors and Affiliations

  1. Department of Surgery, Queen Mary Hospital, University of Hong Kong, Pokfulam, Hong Kong

    Joanna Chung Kiu Mak, Dominic Chi Chung Foo, Rockson Wei & Wai Lun Law

Authors
  1. Joanna Chung Kiu Mak
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  2. Dominic Chi Chung Foo
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  3. Rockson Wei
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  4. Wai Lun Law
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Contributions

JCK Mak was responsible for acquisition of data, analysis of data and drafting of the manuscript. DCC Foo was responsible for conception and design, analysis and interpretation of data and critical revision of the manuscript. R Wei was responsible for acquisition of data and interpretation of data. WL Law was responsible for conception and design, revision and final approval of the manuscript.

Corresponding author

Correspondence to Wai Lun Law.

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Mak, J.C.K., Foo, D.C.C., Wei, R. et al. Sphincter-Preserving Surgery for Low Rectal Cancers: Incidence and Risk Factors for Permanent Stoma. World J Surg 41, 2912–2922 (2017). https://doi.org/10.1007/s00268-017-4090-8

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  • DOI: https://doi.org/10.1007/s00268-017-4090-8

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