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C-Reactive Protein Indicates Early Stage of Postoperative Infectious Complications in Patients Following Minimally Invasive Esophagectomy

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Abstract

Background

Esophagectomy for patients with esophageal cancer is associated with high rate of postoperative infectious complications (PICs). Although minimally invasive esophagectomy (MIE) could reduce the rate of PICs, its incidence cannot be ignored. Early detection of PICs may be beneficial in clinical settings. We investigated whether systemic inflammation markers, such as C-reactive protein (CRP) and white blood cell count (WBC), are useful for the early detection of PICs.

Method

We reviewed 158 patients who underwent MIE from 2000 to 2015 and assessed PIC incidence and severity. The value of CRP and WBC in the early detection of PICs was evaluated by receiver operating characteristics analyses. Univariate and multivariate analyses were performed to identify severe PICs risk factors (Clavien–Dindo classification, grade IIIa or higher).

Results

Thirty patients developed PICs: grades III, IV, and V in 19 (12.0%), 9 (5.7%), and 2 (1.3%) patients, respectively. CRP on 4POD showed the highest value for detection of PICs (AUC = 072). Cutoff value of CRP on 4POD was determined as 11.1 (mg/dL), in which the sensitivity and specificity were the maximum value. The univariate analysis revealed that sex (male), operation time (≥597 min), and CRP on 4POD (≥11.1 mg/dL) were significant factors for detecting PICs. Multivariate analyses showed that operation time (≥597) and CRP on 4POD (≥11.1 mg/dL) were independent significant factors for detecting PICs.

Conclusions

CRP on 4POD ≥11.1 mg/dL was an independent PICs risk factor in patients who underwent MIE. It will be beneficial for the early detection of PICs following MIE.

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Authors and Affiliations

  1. Department of Surgical Oncology, Osaka City University Graduate School of Medicine, 1-4-3, Asahimachi, Abeno-ku, Osaka City, Osaka, 545-8585, Japan

    Yuichiro Miki, Takahiro Toyokawa, Naoshi Kubo, Tatsuro Tamura, Katsunobu Sakurai, Hiroaki Tanaka, Kazuya Muguruma, Masakazu Yashiro, Kosei Hirakawa & Masaichi Ohira

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  1. Yuichiro Miki
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  2. Takahiro Toyokawa
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  3. Naoshi Kubo
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  4. Tatsuro Tamura
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  5. Katsunobu Sakurai
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  6. Hiroaki Tanaka
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  7. Kazuya Muguruma
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  8. Masakazu Yashiro
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  9. Kosei Hirakawa
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  10. Masaichi Ohira
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Correspondence to Takahiro Toyokawa.

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Miki, Y., Toyokawa, T., Kubo, N. et al. C-Reactive Protein Indicates Early Stage of Postoperative Infectious Complications in Patients Following Minimally Invasive Esophagectomy. World J Surg 41, 796–803 (2017). https://doi.org/10.1007/s00268-016-3803-8

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  • DOI: https://doi.org/10.1007/s00268-016-3803-8

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