Abstract
Background
Patients with diabetes are considered at increased risk of delayed wound healing and infectious complications, yet the relationship between diabetes and anastomotic leak (AL) remains unclear. Given that glycosylated hemoglobin (HbA1c) is a validated indicator of the long-term glycemic state, we evaluated the relationship between preoperative HbA1c levels and AL after esophagectomy.
Methods
We assessed 300 consecutive patients who underwent esophagectomy reconstructed with cervical esophagogastric anastomosis between 2011 and 2015. HbA1c levels were measured within 90 days before esophagectomy. We performed comparison between the patients with and without diabetes. In addition, the predictive factors for AL, as well as the relationship between HbA1c levels and AL, were investigated.
Results
Among the 300 patients, 35 had diabetes. The overall prevalence of AL was 11.7%, and patients with diabetes had a higher prevalence of AL than those without (p = 0.045). In univariate analysis, we identified diabetes, HbA1c level, and hand-sewn anastomosis as risk factors for AL significantly (p = 0.033, 0.009, and 0.011, respectively), but we also found previous smoking history, chronic hepatic disease, and supracarinal tumor location also showed tendencies to be risk factors (p = 0.057, 0.055, and 0.064, respectively). Multivariate logistic regression analysis indicated that chronic hepatic disease (p = 0.048), increased HbA1c level (p = 0.011), and hand-sewn anastomosis (p = 0.021) were independent risk factors for AL.
Conclusions
Preoperative HbA1c level was significantly associated with the development of AL after cervical esophagogastric anastomosis. We recommend preoperative HbA1c screening for all patients scheduled to undergo esophagectomy.
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References
Kassis ES, Kosinski AS, Ross P Jr et al (2013) Predictors of anastomotic leak after esophagectomy: an analysis of the society of thoracic surgeons general thoracic database. Ann Thorac Surg 96:1919–1926
Markar S, Gronnier C, Duhamel A et al (2015) The impact of severe anastomotic leak on long-term survival and cancer recurrence after surgical resection for esophageal malignancy. Ann Surg 262:972–980
Jafari MD, Halabi WJ, Smith BR et al (2013) A decade analysis of trends and outcomes of partial versus total esophagectomy in the United States. Ann Surg 258:450–458
Takeuchi H, Miyata H, Gotoh M et al (2014) A risk model for esophagectomy using data of 5354 patients included in a Japanese nationwide web-based database. Ann Surg 260:259–266
Sauvanet A, Mariette C, Thomas P et al (2005) Mortality and morbidity after resection for adenocarcinoma of the gastroesophageal junction: predictive factors. J Am Coll Surg 201:253–262
Junemann-Ramirez M, Awan MY, Khan ZM et al (2005) Anastomotic leakage post-esophagogastrectomy for esophageal carcinoma: retrospective analysis of predictive factors, management and influence on longterm survival in a high volume centre. Eur J Cardiothorac Surg 27:3–7
Wright CD, Kucharczuk JC, O’Brien SM et al (2009) Predictors of major morbidity and mortality after esophagectomy for esophageal cancer: a Society of Thoracic Surgeons General Thoracic Surgery Database risk adjustment model. J Thorac Cardiovasc Surg 137:587–595
Haga Y, Wada Y, Takeuchi H et al (2011) Prediction of anastomotic leak and its prognosis in digestive surgery. World J Surg 35:716–722. doi:10.1007/s00268-010-0922-5
Markar SR, Arya S, Karthikesalingam A et al (2013) Technical factors that affect anastomotic integrity following esophagectomy: systematic review and meta-analysis. Ann Surg Oncol 20:4274–4281
Harustiak T, Pazdro A, Snajdauf M et al (2016) Anastomotic leak and stricture after hand-sewn versus linear-stapled intrathoracic oesophagogastric anastomosis: single-centre analysis of 415 oesophagectomies. Eur J Cardiothorac Surg 49:1650–1659
Wang YJ, Liu XH, Mei LY, et al (2015) Do alterations in plasma albumin and prealbumin after minimally invasive esophagectomy for squamous cell carcinoma influence the incidence of cervical anastomotic leak? Surg Endosc 30:3943–3949
Van Daele E, Van de Putte D, Ceelen W et al (2016) Risk factors and consequences of anastomotic leakage after Ivor Lewis oesophagectomydagger. Interact Cardiovasc Thorac Surg 22:32–37
Trick WE, Scheckler WE, Tokars JI et al (2009) Modifiable risk factors associated with deep sternal site infection after coronary artery bypass grafting. J Thorac Cardiovasc Surg 119:108–114
Richards JE, Kauffmann RM, Zuckerman SL et al (2012) Relationship of hyperglycemia and surgical-site infection in orthopaedic surgery. J Bone Joint Surg Am 94:1181–1186
Martin ET, Kaye KS, Knott C et al (2016) Diabetes and risk of surgical site infection: a systematic review and meta-analysis. Infect Control Hosp Epidemiol 37:88–99
Aminian A, Panahi N, Mirsharifi R et al (2011) Predictors and outcome of cervical anastomotic leakage after esophageal cancer surgery. J Cancer Res Ther 7:448–453
Jeppsson JO, Kobold U, Barr J et al (2002) Approved IFCC reference method for the measurement of HbA1c in human blood. Clin Chem Lab Med 40:78–89
Tennyson C, Lee R, Attia R (2013) Is there a role for HbA1c in predicting mortality and morbidity outcomes after coronary artery bypass graft surgery? Interact Cardiovasc Thorac Surg 17:1000–1008
Koumpan Y, Vandenkerkhof E, van Vlymen J (2014) An observational cohort study to assess glycosylated hemoglobin screening for elective surgical patients. Can J Anaesth 61:407–416
Underwood P, Askari R, Hurwitz S et al (2014) Preoperative A1C and clinical outcomes in patients with diabetes undergoing major noncardiac surgical procedures. Diabetes Care 37:611–616
Iavazzo C, McComiskey M, Datta M et al (2015) Preoperative HBA1c and risk of postoperative complications in patients with gynaecological cancer. Arch Gynecol Obstet 294:161–164
Goodenough CJ, Liang MK, Nguyen MT et al (2015) Preoperative glycosylated hemoglobin and postoperative glucose together predict major complications after abdominal surgery. J Am Coll Surg 221:854–861
Sobin LH, Gospodarowicz MK, Wittekind C et al (2010) TNM classification of malignant tumours. Wiley-Blackwell, Sussex
Kuwano H, Nishimura Y, Oyama T et al (2015) Guidelines for diagnosis and treatment of carcinoma of the esophagus April 2012 edited by the Japan Esophageal Society. Esophagus 12:1–30
Furukawa Y, Hanyu N, Hirai K et al (2005) Usefulness of automatic triangular anastomosis for esophageal cancer surgery using a linear stapler (TA-30). Ann Thorac Cardiovasc Surg 11:80–86
Toh Y, Sakaguchi Y, Ikeda O et al (2009) The triangulating stapling technique for cervical esophagogastric anastomosis after esophagectomy. Surg Today 39:201–206
Yoshida N, Baba Y, Watanabe M et al (2015) Triangulating stapling technique covered with the pedicled omental flap for esophagogastric anastomosis: a safe anastomosis with fewer complications. J Am Coll Surg 220:e13–16
Onodera H, Ikeuchi D, Nagayama S et al (2004) Weakness of anastomotic site in diabetic rats is caused by changes in the integrity of newly formed collagen. Dig Surg 21:146–151
Park S, Rich J, Hanses F et al (2009) Defects in innate immunity predispose C57BL/6 J-Leprdb/Leprdb mice to infection by Staphylococcus aureus. Infect Immun 77:1008–1014
Greenhalgh DG (2003) Wound healing and diabetes mellitus. Clin Plast Surg 30:37–45
Dai JG, Zhang ZY, Min JX et al (2011) Wrapping of the omental pedicle flap around esophagogastric anastomosis after esophagectomy for esophageal cancer. Surgery 149:404–410
Chen L, Liu F, Wang K et al (2014) Omentoplasty in the prevention of anastomotic leakage after oesophagectomy: a meta-analysis. Eur J Surg Oncol 40:1635–1640
Zehetner J, DeMeester SR, Alicuben ET et al (2015) Intraoperative assessment of perfusion of the gastric graft and correlation with anastomotic leaks after esophagectomy. Ann Surg 262:74–78
Shaw P, Saleem T, Gahtan V (2014) Correlation of hemoglobin A1C level with surgical outcomes: Can tight perioperative glucose control reduce infection and cardiac events? Semin Vasc Surg 27:156–161
Boreland L, Scott-Hudson M, Hetherington K et al (2015) The effectiveness of tight glycemic control on decreasing surgical site infections and readmission rates in adult patients with diabetes undergoing cardiac surgery: a systematic review. Heart Lung 4:430–440
Kroin JS, Buvanendran A, Li J et al (2015) Short-term glycemic control is effective in reducing surgical site infection in diabetic rats. Anesth Analg 120:1289–1296
Al-Niaimi AN, Ahmed M, Burish N et al (2015) Intensive postoperative glucose control reduces the surgical site infection rates in gynecologic oncology patients. Gynecol Oncol 136:71–76
Markar SR, Karthikesalingam A, Vyas S et al (2011) Hand-sewn versus stapled oesophago-gastric anastomosis: systematic review and meta-analysis. J Gastrointest Surg 15:876–884
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Okamura, A., Watanabe, M., Imamura, Y. et al. Preoperative Glycosylated Hemoglobin Levels Predict Anastomotic Leak After Esophagectomy with Cervical Esophagogastric Anastomosis. World J Surg 41, 200–207 (2017). https://doi.org/10.1007/s00268-016-3763-z
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DOI: https://doi.org/10.1007/s00268-016-3763-z