Abstract
Background
In patients with persistent (P-PHPT) or recurrent (R-PHPT) primary hyperparathyroidism, preoperative localization is important. Selective parathyroid hormone venous sampling (sPVS) is an invasive technique that can be used to regionalize and/or lateralize the source of PHPT when noninvasive imaging studies are nonlocalizing. The aim of the present study was to assess the role of sPVS in the preoperative evaluation of patients with P-PHPT or R-PHPT and negative, equivocal, or discordant noninvasive imaging localization.
Methods
After IRB-approval a retrospective review of all patients with P-PHPT or R-PHPT and nonlocalizing noninvasive imaging that underwent sPVS from 2000 to 2014 was performed. The location of the source of PHPT at sPVS was predicted by a parathyroid hormone (PTH) gradient and compared to the surgical, pathology, and biochemical follow-up data as the gold standard. Sensitivity and positive predictive value (PPV) were calculated.
Results
Of 30 patients who underwent sPVS, 12 patients did not undergo surgical exploration due to negative or non-localizing PTH gradient (n = 8) or opted for medical management (n = 4). Of the 18 patients who underwent surgical exploration, 17 (94 %) had a positive PTH gradient and pathologic parathyroid tissue identified at surgery. Sensitivity and PPV of sPVS were 93 and 77 %, respectively, for all surgical cases, 86 and 60.0 % for cervical cases (n = 11), and 100 and 100 % for mediastinal cases (n = 7). Sixteen patients (89 %) were surgically cured.
Conclusions
In patients with P-PHPT or R-PHPT and nonlocalizing imaging studies, sPVS is a sensitive test for localizing the source of PHPT when a positive PTH gradient is present.
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References
Griebeler ML, Kearns AE, Ryu E et al (2015) Secular trends in the incidence of primary hyperparathyroidism over five decades (1965–2010). Bone 73:1–7
Yeh MW, Ituarte PH, Zhou HC et al (2013) Incidence and prevalence of primary hyperparathyroidism in a racially mixed population. J Clin Endocrinol Metab 98:1122–1129
Rao DS, Honasoge M, Divine GW et al (2000) Effect of vitamin D nutrition on parathyroid adenoma weight: pathogenetic and clinical implications. J Clin Endocrinol Metab 85:1054–1058
Thompson GB, Grant CS, Perrier ND et al (1999) Reoperative parathyroid surgery in the era of sestamibi scanning and intraoperative parathyroid hormone monitoring. Arch Surg 134:699–704
Udelsman R, Lin Z, Donovan P (2011) The superiority of minimally invasive parathyroidectomy based on 1650 consecutive patients with primary hyperparathyroidism. Ann Surg 253:585–591
Lebastchi AH, Aruny JE, Donovan PI et al (2015) Real-time super selective venous sampling in remedial parathyroid surgery. J Am Coll Surg 220:994–1000
Cheung K, Wang TS, Farrokhyar F et al (2012) A meta-analysis of preoperative localization techniques for patients with primary hyperparathyroidism. Ann Surg Oncol 19:577–583
Kunstman JW, Kirsch JD, Mahajan A et al (2013) Clinical review: parathyroid localization and implications for clinical management. J Clin Endocrinol Metab 98:902–912
Harris PA, Taylor R, Thielke R et al (2009) Research electronic data capture (REDCap)—a metadata-driven methodology and workflow process for providing translational research informatics support. J Biomed Inform 42:377–381
Morris LF, Zanocco K, Ituarte PH et al (2010) The value of intraoperative parathyroid hormone monitoring in localized primary hyperparathyroidism: a cost analysis. Ann Surg Oncol 17:679–685
Sosa JA, Powe NR, Levine MA et al (1998) Cost implications of different surgical management strategies for primary hyperparathyroidism. Surgery 124:1028–1035
Doherty GM, Weber B, Norton JA (1994) Cost of unsuccessful surgery for primary hyperparathyroidism. Surgery 116:954–957
Prommegger R, Wimmer G, Profanter C et al (2009) Virtual neck exploration: a new method for localizing abnormal parathyroid glands. Ann Surg 250:761–765
Witteveen JE, Kievit J, Stokkel MP et al (2011) Limitations of Tc99 m-MIBI-SPECT imaging scans in persistent primary hyperparathyroidism. World J Surg 35:128–139
Udelsman R, Aruny JE, Donovan PI et al (2003) Rapid parathyroid hormone analysis during venous localization. Ann Surg 237:714–719
Witteveen JE, Kievit J, van Erkel AR et al (2010) The role of selective venous sampling in the management of persistent hyperparathyroidism revisited. Eur J Endocrinol 163:945–952
Seehofer D, Steinmuller T, Rayes N et al (2004) Parathyroid hormone venous sampling before reoperative surgery in renal hyperparathyroidism: comparison with noninvasive localization procedures and review of the literature. Arch Surg 139:1331–1338
Lau JH, Drake W, Matson M (2007) The current role of venous sampling in the localization of endocrine disease. Cardiovasc Intervent Radiol 30:555–570
Richards ML, Thompson GB, Farley DR et al (2008) Reoperative parathyroidectomy in 228 patients during the era of minimal-access surgery and intraoperative parathyroid hormone monitoring. Am J Surg 196:937–942
Mortenson MM, Evans DB, Lee JE et al (2008) Parathyroid exploration in the reoperative neck: improved preoperative localization with 4D-computed tomography. J Am Coll Surg 206:888–895
Rodgers SE, Hunter GJ, Hamberg LM et al (2006) Improved preoperative planning for directed parathyroidectomy with 4-dimensional computed tomography. Surgery 140:932–940
Day KM, Elsayed M, Beland MD et al (2015) The utility of 4-dimensional computed tomography for preoperative localization of primary hyperparathyroidism in patients not localized by sestamibi or ultrasonography. Surgery 157:534–539
Ginsburg M, Christoforidis GA, Zivin SP et al (2015) Adenoma localization for recurrent or persistent primary hyperparathyroidism using dynamic four-dimensional CT and venous sampling. J Vasc Interv Radiol 26:79–86
Bancos I, Grant CS, Nadeem S et al (2012) Risks and benefits of parathyroid fine-needle aspiration with parathyroid hormone washout. Endocr Pract 18:441–449
Weber T, Maier-Funk C, Ohlhauser D et al (2013) Accurate preoperative localization of parathyroid adenomas with C-11 methionine PET/CT. Ann Surg 257:1124–1128
Traub-Weidinger T, Mayerhoefer ME, Koperek O et al (2014) 11C-methionine PET/CT imaging of 99mTc-MIBI-SPECT/CT-negative patients with primary hyperparathyroidism and previous neck surgery. J Clin Endocrinol Metab 99:4199–4205
Lenschow C, Gassmann P, Wenning C et al (2015) Preoperative (1)(1)C-methionine PET/CT enables focused parathyroidectomy in MIBI-SPECT negative parathyroid adenoma. World J Surg 39:1750–1757
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Sun, P.Y., Thompson, S.M., Andrews, J.C. et al. Selective Parathyroid Hormone Venous Sampling in Patients with Persistent or Recurrent Primary Hyperparathyroidism and Negative, Equivocal or Discordant Noninvasive Imaging. World J Surg 40, 2956–2963 (2016). https://doi.org/10.1007/s00268-016-3621-z
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DOI: https://doi.org/10.1007/s00268-016-3621-z