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Feasibility of Nipple-Sparing Mastectomy with Immediate Breast Reconstruction in Breast Cancer Patients with Tumor-Nipple Distance Less Than 2.0 cm

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Abstract

Background and objective

Debate continues concerning the oncological risk of nipple-sparing mastectomy (NSM) with immediate breast reconstruction (IBR) if the tumor-nipple distance (TND) is less than 2.0 cm. In this retrospective study, we analyzed oncological outcomes after NSM with IBR for the treatment of breast cancer to determine the risk posed by NSM in cases in which magnetic resonance imaging (MRI) showed a TND <2.0 cm but intraoperative frozen biopsy results were negative for tumor cells at the nipple base.

Materials and methods

We conducted a retrospective review of patients with breast cancer who underwent NSM with IBR at Samsung Medical Center between 2008 and 2014. Preoperative MRI was done in all cases to define the TND, and frozen biopsy specimens were obtained intraoperatively.

Results

Among the 266 NSMs performed, TND was <2.0 cm in 145 cases (54.5 %) and ≥2.0 cm in 121 cases (45.5 %). Median follow-up was 25.6 months. There were no significant differences between the two patient groups with respect to disease-free survival or local recurrence-free survival.

Conclusion

Our results suggest that NSM can be a feasible treatment option when the intraoperative frozen biopsy is negative for tumor cells even with a TND <2.0 cm in MRI.

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Authors and Affiliations

  1. Division of Breast and Endocrine Surgery, Department of Surgery, Samsung Medical Center Cancer Hospital, School of Medicine, Sungkyunkwan University, 5th Floor, Irwon-ro 81, Gangnam-gu, Seoul, 135-710, Korea

    Jai Min Ryu, Seok Jin Nam, Seok Won Kim, Se Kyung Lee, Soo Youn Bae, Ha Woo Yi, Sungmin Park, Hyun-June Paik & Jeong Eon Lee

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  1. Jai Min Ryu
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Correspondence to Jeong Eon Lee.

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Ryu, J.M., Nam, S.J., Kim, S.W. et al. Feasibility of Nipple-Sparing Mastectomy with Immediate Breast Reconstruction in Breast Cancer Patients with Tumor-Nipple Distance Less Than 2.0 cm. World J Surg 40, 2028–2035 (2016). https://doi.org/10.1007/s00268-016-3487-0

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  • DOI: https://doi.org/10.1007/s00268-016-3487-0

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