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Low Nutritional Prognostic Index Correlates with Poor Survival in Patients with Stage IV Colorectal Cancer Following Palliative Resection of the Primary Tumor

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Abstract

Background

We retrospectively investigated the prognostic significance of various clinicopathological factors and preoperative nutritional status to select patients with stage IV colorectal cancer (CRC) who will have a poor prognosis after palliative resection of the primary tumor.

Methods

A total of 100 stage IV CRC patients who underwent palliative resection were enrolled. Various clinicopathological factors and Onodera’s prognostic nutritional index (OPNI) were evaluated to identify any possible relationship with the prognosis.

Results

At the time of the analysis, 83 patients had died, and the median survival time was 21 months. Of the 100 patients, 24 had primary tumor-related symptoms such as obstruction or bleeding. No significant correlation was noted between the OPNI and various clinicopathological factors. The multivariate analysis of patients without primary tumor-related symptoms revealed that the OPNI was an independent prognostic factor. The overall survival of the low-OPNI group was significantly worse than that of the high-OPNI group.

Conclusions

This retrospective study suggested that patients with a low OPNI may not be candidates for palliative resection, because it provides no survival benefit to these patients.

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Authors and Affiliations

  1. Department of Surgical Oncology, Osaka City University Graduate School of Medicine, 1-4-3 Asahimachi, Abeno-ku, Osaka, Japan

    Kiyoshi Maeda, Masatsune Shibutani, Hiroshi Otani, Hisashi Nagahara, Kenji Sugano, Teturo Ikeya, Naoshi Kubo, Ryosuke Amano, Kenjiro Kimura, Kazuya Muguruma, Hiroaki Tanaka & Kosei Hirakawa

Authors
  1. Kiyoshi Maeda
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  2. Masatsune Shibutani
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  3. Hiroshi Otani
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  4. Hisashi Nagahara
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  5. Kenji Sugano
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  6. Teturo Ikeya
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  7. Naoshi Kubo
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  8. Ryosuke Amano
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  9. Kenjiro Kimura
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  10. Kazuya Muguruma
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  11. Hiroaki Tanaka
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  12. Kosei Hirakawa
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Correspondence to Kiyoshi Maeda.

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Maeda, K., Shibutani, M., Otani, H. et al. Low Nutritional Prognostic Index Correlates with Poor Survival in Patients with Stage IV Colorectal Cancer Following Palliative Resection of the Primary Tumor. World J Surg 38, 1217–1222 (2014). https://doi.org/10.1007/s00268-013-2386-x

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  • DOI: https://doi.org/10.1007/s00268-013-2386-x

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