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Influence of Preoperative Chemotherapy on the Intraoperative and Postoperative Course of Liver Resection for Colorectal Cancer Metastases

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Abstract

Background

Liver resection is a possibly curative treatment for colorectal cancer (CRC) liver metastases. Preoperative chemotherapy may make initially irresectable tumors resectable. The aim of this study was to compare perioperative course and short-term mortality after liver resection for CRC metastases between patients who were and were not treated with preoperative chemotherapy.

Methods

Patients who had undergone liver resection for CRC metastases were included. A total of 97 patients treated with preoperative chemotherapy (group A) were compared with 136 who were not (group B). Intraoperative bleeding, operating time, complications, duration of stay, and mortality were compared using Pearson’s χ2 test, Fisher’s exact test, and the Mann–Whitney U-test.

Results

Mean intraoperative bleeding, duration of stay, and operating time were not significantly different. Complications occurred in 62.9% and 63.2% in groups A and B, respectively. The 30- and 90-day mortality rates were zero in group A, comparable to 1.5% in group B.

Conclusions

There were no significant differences in the perioperative course or postoperative mortality when comparing CRC patients with or without chemotherapy prior to liver resection. Consequently, this study suggests that preoperative chemotherapy before liver resection for CRC metastases does not negatively influence perioperative outcome and can therefore be applied if “downstaging” is indicated.

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Conflicts of interest

There are no conflicts of interest to be declared. No financial support was requested or received in the production of this article.

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Authors and Affiliations

  1. Department of Surgery, Clinical Sciences Lund, Skåne University Hospital Lund, Lund University, Lund, 22185, Sweden

    Lidewij Spelt, Lina Hermansson, Bobby Tingstedt & Roland Andersson

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  1. Lidewij Spelt
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  2. Lina Hermansson
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  3. Bobby Tingstedt
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  4. Roland Andersson
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Correspondence to Roland Andersson.

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Spelt, L., Hermansson, L., Tingstedt, B. et al. Influence of Preoperative Chemotherapy on the Intraoperative and Postoperative Course of Liver Resection for Colorectal Cancer Metastases. World J Surg 36, 157–163 (2012). https://doi.org/10.1007/s00268-011-1342-x

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  • DOI: https://doi.org/10.1007/s00268-011-1342-x

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