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How Radical Should Surgery Be for Early Esophageal Cancer?

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Abstract

Background

We have compared the oncologic effectiveness of limited resection (LR) techniques such as transhiatal (TH) or limited resection of the esophagogastric junction with intestinal interposition (LREGJ) in the treatment of early esophageal carcinoma with that of the extended resection such as the classical thoracoabdominal (TA) en bloc esophagectomy.

Methods

We performed a retrospective analysis of prospectively collected data of 113 patients with T1 esophageal cancer (57 adeno- and 56 squamous cell carcinomas) who had surgical resection with systematic lymphadenectomy. Forty-one underwent extensive (TA) and 72 limited resection (51 TH and 21 LREGJ).

Results

Complete resection (R0) was achieved in all cases. Lymphatic metastases were seen in none of the mucosal but in 26.8% of the submucosal T1 cancers. The median lymph node yield was significantly higher in patients with extensive resection (24 vs. 15 lymph nodes; p = 0.036), but this did not affect the overall survival (median = 88 vs. 102 months, 5-year survival probability = 57.8 vs. 67.7%; log rank = 0.578). The median hospital stay and ICU stay were significantly shorter in the LR group (p = 0.039 and p = 0.044, respectively).

Conclusion

Limited resection leads to lower lymph node yield but similar oncologic effectiveness as the extensive surgery. It may represent a valuable alternative in the treatment of patients with early (submucosal) esophageal carcinoma.

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Authors and Affiliations

  1. Department of General, Visceral and Thoracic Surgery, University Hospital Hamburg-Eppendorf, Martinistrasse 52, 20246, Hamburg, Germany

    Dean Bogoevski, Maximilian Bockhorn, Alexandra Koenig, Matthias Reeh, Katharina von Loga & Jakob R. Izbicki

  2. Institute of Pathology, University Hospital Hamburg-Eppendorf, Hamburg, Germany

    Guido Sauter

  3. Department of Interdisciplinary Endoscopy, University Hospital Hamburg-Eppendorf, Hamburg, Germany

    Thomas Rösch

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  1. Dean Bogoevski
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  2. Maximilian Bockhorn
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  3. Alexandra Koenig
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  4. Matthias Reeh
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  5. Katharina von Loga
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  6. Guido Sauter
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  7. Thomas Rösch
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  8. Jakob R. Izbicki
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Corresponding author

Correspondence to Dean Bogoevski.

Additional information

D. Bogoevski and M. Bockhorn contributed equally to this work.

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Bogoevski, D., Bockhorn, M., Koenig, A. et al. How Radical Should Surgery Be for Early Esophageal Cancer?. World J Surg 35, 1311–1320 (2011). https://doi.org/10.1007/s00268-011-1069-8

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