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Intensive Versus Conventional Insulin Therapy in Type 2 Diabetes Patients Undergoing D2 Gastrectomy for Gastric Cancer: A Randomized Controlled Trial

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Abstract

Background

This study was to compare the effect of intensive insulin therapy (IIT) to conventional insulin therapy (CIT) on postoperative outcomes among type 2 diabetes mellitus (DM) patients who underwent D2 gastrectomy for gastric cancer.

Methods

We randomly assigned gastric cancer patients with type 2 DM who underwent radical gastrectomy to receive IIT (maintenance of blood glucose at a level between 4.4 and 6.1 mmol/l) with insulin infusion or CIT (maintenance of blood glucose at a level between 10 and 11.1 mmol/l) during the postoperative period.

Results

Of the 179 eligible patients, 92 patients were assigned to receive IIT and 87 patients to receive CIT. Mean blood glucose concentrations were lower in the intensive group (IG) than in the conventional group (CG) (5.5 ± 0.8 vs. 9.9 ± 1.0 mmol/l, P < 0.001). Hypoglycemia occurred in 6 patients (6.5%) in the IG (P = 0.029) versus in 1 patient (1.1%) in the CG. Hospital mortality did not differ significantly between two groups (4.3% vs. 5.7%, P = 0.742). However, IIT significantly reduced morbidity (from 18.4 to 7.6%, P = 0.031). Also, IIT shortened the days to suture removal, postoperative hospital stay, and postoperative duration of antibiotic use. The HOMA-IR score was lower at all time points in IG. Moreover, IIT increased the postoperative HLA-DR expression on monocytes on postoperative days 3 and 5.

Conclusions

IIT significantly reduced short-term morbidity but not mortality among type 2 DM patients who underwent D2 gastrectomy for gastric cancer. Furthermore, a possible mechanism of suppression of the insulin resistance and improvement of HLA-DR expression may partially explain the benefits of IIT.

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Acknowledgment

This study was partially supported by the Health Science and Technology Development Project of Shandong (2005HZ024).

Conflict of interest

There is no potential and real conflict to any third party.

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Authors and Affiliations

  1. Medical School of Nanjing University, Institute of General Surgery, Jinling Hospital, Nanjing, Jiangsu, 210002, China

    Shou-Gen Cao, Jian-An Ren, Bo Shen & Jie-Shou Li

  2. Department of General Surgery, Affiliated Hospital of Medical College Qingdao University, No.19 Jiangsu Road, Qingdao, Shandong, 266002, China

    Dong Chen & Yan-Bing Zhou

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  1. Shou-Gen Cao
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  2. Jian-An Ren
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  4. Dong Chen
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Correspondence to Yan-Bing Zhou.

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Cao, SG., Ren, JA., Shen, B. et al. Intensive Versus Conventional Insulin Therapy in Type 2 Diabetes Patients Undergoing D2 Gastrectomy for Gastric Cancer: A Randomized Controlled Trial. World J Surg 35, 85–92 (2011). https://doi.org/10.1007/s00268-010-0797-5

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  • DOI: https://doi.org/10.1007/s00268-010-0797-5

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