Abstract
Background
Because of co-morbidity, adrenalectomy for adrenal Cushing’s syndrome may be associated with an increased complication rate and long operating times. In the present study we report our experience with the posterior retroperitoneoscopic adrenalectomy in a large group of patients with clinical or subclinical Cushing’s syndrome.
Patients and methods
Between July 1994 and June 2009, 170 patients (17 males, 153 females age 50 ± 13 years; range: 12–78 years) affected by Cushing’s syndrome underwent operation via posterior retroperitoneoscopic access. Patients were divided into two groups, those with manifest Cushing’s syndrome (mCS) [99 patients: 6 male, 93 female; age 45 ± 13 years] and those with subclinical Cushing’s syndrome (sCS) [71 patients: 11 male, 60 female; age: 56 ± 11 years]. The sCS classification was assumed in cases without typical clinical symptoms but with a pathological dexamethasone suppression test. Partial adrenalectomy was performed in 35 cases (24 in the mCS-group and 11 in the sCS-group).
Results
Mortality was zero; major complications did not occur. The incidence of postoperative minor complications was 5.3%. Mean operating time was 58 ± 36 min (range: 20–230 min) and did not differ between mCS and sCS patients (58 versus 59 min; p = ns). Postoperative oral steroids supplementation (POSS) was administered in 136 patients (99 mCS, 37 sCS). If POSS was started, mean duration of therapy was 12.3 months (mCS) and 10.3 months (sCS) [p = 0.08], respectively. After a mean follow-up of 70.9 ± 46.5 months the cure rate was 99.4%.
Conclusions
The posterior retroperitoneoscopic approach is fast and safe even in patients with Cushing’s syndrome. Partial adrenalectomy represents a new option in the treatment of cortisol-producing adenomas.
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References
Arnaldi G, Angeli A, Atkinson AB et al (2003) Diagnosis and complications of Cushing’s syndrome: a consensus statement. J Clin Endocrinol Metab 88:5593–5602
Sarkar R, Thompson NW, McLeod MK (1990) The role of adrenalectomy in Cushing’s syndrome. Surgery 108:1079–1084
Scott HW Jr, Abumrad NN, Orth DN (1985) Tumors of the adrenal cortex and Cushing’s syndrome. Ann Surg 201:586–594
Gagner M, Lacroix A, Bolté E (1992) Laparoscopic adrenalectomy in Cushing’s syndrome and pheochromocytoma. N Engl J Med 327:1033
Fernández-Cruz L, Saenz A, Benarroch G et al (1996) Laparoscopic unilateral and bilateral adrenalectomy for Cushing’s syndrome. Transperitoneal and retroperitoneal approaches. Ann Surg 224:727–734 (discussion 734–736)
Walz MK, Peitgen K, Walz MV et al (2001) Posterior retroperitoneoscopic adrenalectomy: lessons learned within five years. World J Surg 25:728–734
Nieman LK, Biller BM, Findling JW et al (2008) The diagnosis of Cushing’s syndrome: an Endocrine Society Clinical Practice Guideline. J Clin Endocrinol Metab 93:1526–1540
Walz MK, Peitgen K, Krause U et al (1995) Dorsal retroperitoneoscopic adrenalectomy—a new surgical technique. Zentralbl Chir 120:53–58
Walz MK, Peitgen K, Hoermann R et al (1996) Posterior retroperitoneoscopy as a new minimally invasive approach for adrenalectomy: results of 30 adrenalectomies in 27 patients. World J Surg 20:769–774
Walz MK, Alesina PF, Wenger FA et al (2006) Posterior retroperitoneoscopic adrenalectomy—results of 560 procedures in 520 patients. Surgery 140:943–948 (discussion 948–950)
Walz MK, Alesina PF (2009) Single access retroperitoneoscopic adrenalectomy (SARA)—one step beyond in endocrine surgery. Langenbecks Arch Surg 394:447–450
Lombardi CP, Raffaelli M, De Crea C et al (2008) Endoscopic adrenalectomy: is there an optimal operative approach? Results of a single-center case-control study. Surgery 144:1008–1014 (discussion 1014–1015)
Henry JF, Sebag F, Iacobone M et al (2002) Lessons learned from 274 laparoscopic adrenalectomies. Ann Chir 127:512–519
Gagner M, Pomp A, Heniford BT et al (1997) Laparoscopic adrenalectomy: lessons learned from 100 consecutive procedures. Ann Surg 226:238–246 (discussion 246–247)
Kazaryan AM, Marangos IP, Rosseland AR et al (2009) Laparoscopic adrenalectomy: Norwegian single-center experience of 242 procedures. J Laparoendosc Adv Surg Tech A 19:181–189
Bjornsson B, Birgisson G, Oddsdottir M (2008) Laparoscopic adrenalectomies: a nationwide single-surgeon experience. Surg Endosc 22:622–626
Lezoche E, Guerrieri M, Crosta F et al (2008) Perioperative results of 214 laparoscopic adrenalectomies by anterior transperitoneal approach. Surg Endosc 22:522–526
Walz MK, Alesina PF, Wenger FA et al (2006) Laparoscopic and retroperitoneoscopic treatment of pheochromocytomas and retroperitoneal paragangliomas: results of 161 tumors in 126 patients. World J Surg 30:899–908
Walz MK, Gwosdz R, Levin SL et al (2008) Retroperitoneoscopic adrenalectomy in Conn’s syndrome caused by adrenal adenomas or nodular hyperplasia. World J Surg 32:847–853
Priestley JT, Sprague RG, Walters W et al (1951) Subtotal adrenalectomy for Cushing’s syndrome: a preliminary report of 29 cases. Ann Surg 134:464–475
Meyer A, Behrend M (2004) Cushing’s syndrome: adrenalectomy and long-term results. Dig Surg 21:363–370
Iacobone M, Mantero F, Basso SM et al (2005) Results and long-term follow-up after unilateral adrenalectomy for ACTH-independent hypercortisolism in a series of fifty patients. J Endocrinol Invest 28:327–332
Mishra AK, Agarwal A, Gupta S et al (2007) Outcome of adrenalectomy for Cushing’s syndrome: experience from a tertiary care center. World J Surg 31:1425–1432
Sippel RS, Elaraj DM, Kebebew E et al (2008) Waiting for change: symptom resolution after adrenalectomy for Cushing’s syndrome. Surgery 144:1054–1060 (discussion 1060–1061)
Cheng SP, Saunders BD, Gauger PG et al (2008) Laparoscopic partial adrenalectomy for bilateral pheochromocytomas. Ann Surg Oncol 15:2506–2508
Kok KY, Yapp SK (2002) Laparoscopic adrenal-sparing surgery for primary hyperaldosteronism due to aldosterone-producing adenoma. Surg Endosc 16:108–111
Iacobone M, Albiger N, Scaroni C et al (2008) The role of unilateral adrenalectomy in ACTH-independent macronodular adrenal hyperplasia (AIMAH). World J Surg 32:882–889
Young WF Jr, du Plessis H, Thompson GB et al (2008) The clinical conundrum of corticotropin-independent autonomous cortisol secretion in patients with bilateral adrenal masses. World J Surg 32:856–862
Shen WT, Lee J, Kebebew E et al (2006) Selective use of steroid replacement after adrenalectomy: lessons from 331 consecutive cases. Arch Surg 141:771–774 (discussion 774–776)
Reincke M, Nieke J, Krestin GP et al (1992) Preclinical Cushing’s syndrome in adrenal “incidentalomas”: comparison with adrenal Cushing’s syndrome. J Clin Endocrinol Metab 75:826–832
Rossi R, Tauchmanova L, Luciano A et al (2000) Subclinical Cushing’s syndrome in patients with adrenal incidentaloma: clinical and biochemical features. J Clin Endocrinol Metab 85:1440–1448
Erbil Y, Ademoğlu E, Ozbey N et al (2008) Evaluation of the cardiovascular risk in patients with subclinical Cushing syndrome before and after surgery. World J Surg 30:1665–1671
Toniato A, Merante-Boschin I, Opocher G et al (2009) Surgical versus conservative management for subclinical Cushing syndrome in adrenal incidentalomas: a prospective randomized study. Ann Surg 249:388–391
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Alesina, P.F., Hommeltenberg, S., Meier, B. et al. Posterior Retroperitoneoscopic Adrenalectomy for Clinical and Subclinical Cushing’s Syndrome. World J Surg 34, 1391–1397 (2010). https://doi.org/10.1007/s00268-010-0453-0
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DOI: https://doi.org/10.1007/s00268-010-0453-0