Abstract
Background
A fine needle aspiration (FNA) diagnosis of a Hürthle cell neoplasm is associated with a 20% risk of malignancy. We sought to determine if the primary tumor size correlated with the risk of malignancy in patients with a preoperative FNA diagnosis of a Hürthle cell neoplasm.
Methods
Between January 2000 and November 2006, 57 patients underwent a thyroidectomy with a preoperative FNA diagnosis of a Hürthle cell neoplasm. Patient histories, FNA reports, operative notes, and pathology reports were retrospectively reviewed. Statistical analysis was performed.
Results
The overall rate of malignancy in patients with Hürthle cell neoplasms was 21%. The average tumor size was 3.2 cm, with malignant tumors being significantly larger than benign tumors (5.0 vs. 2.7 cm, p < 0.01). The risk of malignancy directly correlated with tumor size. No malignancies were seen in tumors 2 cm or smaller (0/15). The risk of malignancy was only 13% (6/46) in tumors 4 cm or smaller and increased to 55% (6/11) in tumors larger than 4 cm. All tumors larger than 6 cm were malignant (4/4).
Conclusions
Tumor size correlates directly with malignant potential in patients with Hürthle cell neoplasms of the thyroid. Among our patients, malignancy was not present in any tumors 2 cm or smaller and was present in all tumors larger than 6 cm. Because the risk of malignancy is greater than 50% in patients with a tumor larger than 4 cm, consideration should be given for an initial total thyroidectomy in these patients.
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References
Hundahl SA, Fleming ID, Fremgen AM, et al. (1998) A National Cancer Data Base report on 53,856 cases of thyroid carcinoma treated in the U.S., 1985–1995 [see comments]. Cancer 83(12):2638–2648
Lopez-Penabad L, Chiu AC, Hoff AO, et al. (2003) Prognostic factors in patients with Hürthle cell neoplasms of the thyroid. Cancer 97(5):1186–1194
Gundry SR, Burney RE, Thompson NW, et al. (1983) Total thyroidectomy for Hürthle cell neoplasm of the thyroid. Arch Surg 118(5):529–532
Kushchayeva Y, Duh QY, Kebebew E, et al. (2004) Prognostic indications for Hürthle cell cancer. World J Surg 28(12):1266–1270
Maxwell EL, Palme CE, Freeman J (2006) Hürthle cell tumors: applying molecular markers to define a new management algorithm. Arch Otolaryngol Head Neck Surg 132(1):54–58
Finley DJ, Zhu B, Fahey TJ 3rd (2004) Molecular analysis of Hürthle cell neoplasms by gene profiling. Surgery 136(6):1160–1168
Hawasli A, Rizzo P, Khoury H, et al. (2002) Can fine-needle aspiration biopsy of thyroid nodule help in determining the extent of surgery in follicular and Hürthle cell neoplasm at a community teaching institution? Am Surg 68(10):907–910
Pisanu A, Sias L, Uccheddu A (2004) Factors predicting malignancy of Hürthle cell tumors of the thyroid: influence on surgical treatment. World J Surg 28(8):761–765
Chen H, Nicol TL, Zeiger MA, et al. (1998) Hürthle cell neoplasms of the thyroid: are there factors predictive of malignancy? Ann Surg 227(4):542–546
Chao TC, Lin JD, Chen MF (2005) Surgical treatment of Hurthle cell tumors of the thyroid. World J Surg 29(2):164–168
McHenry CR, Thomas SR, Slusarczyk SJ, et al. (1999) Follicular or Hürthle cell neoplasm of the thyroid: can clinical factors be used to predict carcinoma and determine extent of thyroidectomy? Surgery 126(4):798–802; discussion 802–804
Melck A, Bugis S, Baliski C, et al. (2006) Hemithyroidectomy: the preferred initial surgical approach for management of Hürthle cell neoplasm. Am J Surg 191(5):593–597
Gauger PG, Reeve TS, Delbridge LW (1999) Intraoperative decision making in follicular lesions of the thyroid: is tumor size important? J Am Coll Surg 189(3):253–258
Sangalli G, Serio G, Zampatti C, et al. (2006) Fine needle aspiration cytology of the thyroid: a comparison of 5469 cytological and final histological diagnoses. Cytopathology 17(5):245–250
de Vos tot Nederveen Cappel RJ, Bouvy ND, Bonjer HJ, et al. (2001) Fine needle aspiration cytology of thyroid nodules: how accurate is it and what are the causes of discrepant cases? Cytopathology 12(6):399–405
Giorgadze T, Rossi ED, Fadda G, et al. (2004) Does the fine-needle aspiration diagnosis of “Hürthle-cell neoplasm/follicular neoplasm with oncocytic features” denote increased risk of malignancy? Diagn Cytopathol 31(5):307–312
Taneri F, Tekin E, Salman B, et al. (2000) Huerthle cell neoplasms of the thyroid: predicting malignant potential. Endocr Regul 34(1):19–21
Duran C, Saraydaroglu O, Ersoy C, et al. (2006) Tumor size predictive for malignancy in indeterminate follicular thyroid lesions. Endocrinologist 16(6):313–316
Paunovic I, Krgovic K, Tatic S, et al. (2006) Surgery for thyroid Hürthle cell tumours–a single institution experience. Eur J Surg Oncol 32(4):458–461
Sugino K, Ito K, Mimura T, et al. (2001) Hürthle cell tumor of the thyroid: analysis of 188 cases. World J Surg 25(9):1160–1163
Alaedeen DI, Khiyami A, McHenry CR (2005) Fine-needle aspiration biopsy specimen with a predominance of Hürthle cells: a dilemma in the management of nodular thyroid disease. Surgery 138(4):650–656; discussion 656–657
Baloch ZW, Livolsi VA (2002) Follicular-patterned lesions of the thyroid: the bane of the pathologist. Am J Clin Pathol 117(1):143–150
Hundahl SA, Cady B, Cunningham MP, et al. (2000) Initial results from a prospective cohort study of 5583 cases of thyroid carcinoma treated in the united states during 1996. U.S. and German Thyroid Cancer Study Group. An American College of Surgeons Commission on Cancer Patient Care Evaluation study. Cancer 89(1):202–217
Pu RT, Yang J, Wasserman PG, et al. (2006) Does Hürthle cell lesion/neoplasm predict malignancy more than follicular lesion/neoplasm on thyroid fine-needle aspiration? Diagn Cytopathol 34(5):330–334
Elliott DD, Pitman MB, Bloom L, et al. (2006) Fine-needle aspiration biopsy of Hürthle cell lesions of the thyroid gland: A cytomorphologic study of 139 cases with statistical analysis. Cancer 108(2):102–109
Kauffmann PR, Dejax C, de Latour M, et al. (2004) The meaning and predictivity of Hürthle cells in fine needle aspiration cytology for thyroid nodular disease. Eur J Surg Oncol 30(7):786–789
Oertel YC, Oertel JE (2000) Thyroid cytology and histology. Baillieres Best Pract Res Clin Endocrinol Metab 14(4):541–557
Fearon ER, Vogelstein B (1990) A genetic model for colorectal tumorigenesis. Cell 61(5):759–767
Fagin JA, Matsuo K, Karmakar A, et al. (1993) High prevalence of mutations of the p53 gene in poorly differentiated human thyroid carcinomas. J Clin Invest 91(1):179–184
Wynford-Thomas D (1997) Origin and progression of thyroid epithelial tumours: cellular and molecular mechanisms. Horm Res 47(4–6):145–157
Wada N, Duh QY, Miura D, et al. (2002) Chromosomal aberrations by comparative genomic hybridization in hurthle cell thyroid carcinomas are associated with tumor recurrence. J Clin Endocrinol Metab 87(10):4595–4601
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This work was supported in part by Friends of Endocrinology, The Gerald Heller Family Foundation, The Helen and Sanford Diller Foundation, and the Bell Charitable Trust.
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Sippel, R.S., Elaraj, D.M., Khanafshar, E. et al. Tumor Size Predicts Malignant Potential in Hürthle Cell Neoplasms of the Thyroid. World J Surg 32, 702–707 (2008). https://doi.org/10.1007/s00268-007-9416-5
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DOI: https://doi.org/10.1007/s00268-007-9416-5