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Cytoreductive Surgery and Intraperitoneal Chemohyperthermia for Chemoresistant and Recurrent Advanced Epithelial Ovarian Cancer: Prospective Study of 81 Patients

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Abstract

Purpose

There is no standardized treatment for patients with chemoresistant or recurrent advanced ovarian cancer. Locoregional treatments combining cytoreductive surgery and intraperitoneal chemohyperthermia (HIPEC) may improve survival for locoregional disease.

Patients and methods

A prospective single center study of 81 patients with recurrent or chemoresistant peritoneal carcinomatosis from ovarian cancer was performed. Patients were treated by maximal cytoreductive surgery combined with HIPEC (with cisplatinum at 20 mg/m²/L). A total of 47 patients were included for their third, fourth, fifth, sixth, or seventh surgical look. Altogether, 54 patients presented with extensive carcinomatosis (malignant nodules of >5 mm).

Results

Complete macroscopic resection (CCR-0) was achieved in 45 patients. Mortality and morbidity rates were 2.5% and 13.6%, respectively. With a median follow-up of 47.1 months, the overall and disease-free median survivals were 28.4 and 19.2 months, respectively. Carcinomatosis extent and completeness of cytoreduction (p = 0.02 and p <0.001, respectively) were identified as independent prognostic factors. For CCR-0 patients, overall and disease-free survivals were 54.9 and 26.9 months, respectively.

Conclusion

Salvage therapy combining optimal cytoreductive surgery and HIPEC may achieve long-term survival in selected patients with recurrent or chemoresistant ovarian cancer. This strategy may be most effective in patients with limited carcinomatosis or when cytoreductive surgery provides sufficient downstaging.

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Authors and Affiliations

  1. Department of Oncologic Surgery, Centre Hospitalo-Universitaire Lyon Sud, 69495, Pierre Bénite, Cedex, France

    Eddy Cotte, Olivier Glehen, Franck Lamy & Francois Noel Gilly

  2. EA 3738, UCBL, Faculté de Médicine Lyon Sud, BP 12, 69921, Oullins, Cedex, France

    Eddy Cotte, Olivier Glehen, Franck Lamy, Claire Falandry, François Golfier & Francois Noel Gilly

  3. School of Surgical and Reproductive Sciences, Newcastle upon Tyne, UK

    Faheez Mohamed

  4. Department of Medical Oncology, CHLS–HCL, 69495, Pierre Bénite, Cedex, France

    Claire Falandry

  5. Department of Gynecologic surgery, Centre Hospitalo-Universitaire Lyon Sud, 69495, Pierre Bénite, Cedex, France

    François Golfier

Authors
  1. Eddy Cotte
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  2. Olivier Glehen
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  3. Faheez Mohamed
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  4. Franck Lamy
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  5. Claire Falandry
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  6. François Golfier
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  7. Francois Noel Gilly
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Correspondence to Olivier Glehen.

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Cotte, E., Glehen, O., Mohamed, F. et al. Cytoreductive Surgery and Intraperitoneal Chemohyperthermia for Chemoresistant and Recurrent Advanced Epithelial Ovarian Cancer: Prospective Study of 81 Patients. World J Surg 31, 1813–1820 (2007). https://doi.org/10.1007/s00268-007-9146-8

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  • DOI: https://doi.org/10.1007/s00268-007-9146-8

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