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Clinical Significance of Lymph Node Metastasis of Thyroid Papillary Carcinoma Located in One Lobe

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Abstract

Background

Previous studies have shown that lymph node metastasis can be of prognostic value. In this study, we investigated the clinical significance of node metastasis focusing on metastasis in the central compartment for patients with papillary carcinoma located in one lobe.

Patients and Methods

We investigated the frequency of lymph node metastasis in 759 patients with papillary carcinoma to determine whether and how such metastasis affects disease-free survival (DFS).

Results

Central node metastasis was observed in 63% of patients, and the frequency was increased in relation to tumor size. The frequency of lateral node metastasis was 62.0%, which was also directly related to tumor size. On multivariate analysis of cases showing tumor larger than 1 cm, central node metastasis was recognized as an independent prognostic factor of DFS. The frequency of metastasis to the paratracheal nodes contralateral to the tumor was drastically elevated for tumors larger than 1 cm, but metastasis to this region did not independently predict worse DFS.

Conclusion

Central node metastasis independently predicts a worse DFS for patients with papillary carcinoma larger than 1 cm.

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References

  1. Mazzaferri EL, Young RL. Papillary thyroid carcinoma: a 10 year follow-up report of the impact of therapy in 576 patients. Am J Med 1994;97:418–428

    Article  PubMed  CAS  Google Scholar 

  2. Salvesen H, Njolstad PR, Akslen LA, et al. Papillary thyroid carcinoma: a multivariate analysis of prognostic factors including an evaluation of the p-TNM staging system. Eur J Sur 1992;158:583–589

    CAS  Google Scholar 

  3. Akslen LA, Myking AO, Salvesen H, et al. Prognostic importance of various clinicopathological features in papillary thyroid carcinoma. Eur J Cancer 1992;29:44–51

    Article  Google Scholar 

  4. Dralle H, Gimm O. Lymph node excision in thyroid carcinoma. Chirurg 1996;67:788–806

    Article  PubMed  CAS  Google Scholar 

  5. Scheumann GF, Gimm O, Wegener G, et al. Prognostic significance and surgical management of locoregional lymph node metastases in papillary thyroidcancer. World J Surg 1994;18:559–567

    Article  PubMed  CAS  Google Scholar 

  6. Noguchi M, Kumaki T, Taniya T, et al. Impact of neck dissection on survival in well-differentiated thyroid cancer: a multivariate analysis of 218 cases. Int Surg 1990;75:220–224

    PubMed  CAS  Google Scholar 

  7. Bellantone R, Pio Lombardi C, Boscherini M, et al. Prognostic factors in differentiated thyroid carcinoma: a multivariate analysis of 234 consecutive patients. J Surg Oncol 1998;68:237–241

    Article  PubMed  CAS  Google Scholar 

  8. Bottger T, Kupp J, Gabbert HE, et al. Prognostically relevant factors in papillary thyroid cancer. Med Klin 1991;86:76–82

    Google Scholar 

  9. Shaha AR, Shah JP, Loree TR. Risk group stratification and prognostic factors in papillary carcinoma of thyroid. Ann Surg Oncol 1996;3:534–538

    Article  PubMed  CAS  Google Scholar 

  10. Steinmuller T, Klupp J, Rayes N, et al. Prognostic factors in patients with differentiated thyroid carcinoma. Eur J Surg 2000;166:29–33

    Article  PubMed  CAS  Google Scholar 

  11. Antonelli A, Miccoli P, Ferdeghini M. Role of neck ultrasonography in follow-up of patients operated on for differentiated thyroid cancer. Thyroid 1995;5:25–29

    Article  PubMed  CAS  Google Scholar 

  12. Ito Y, Tomoda C, Uruno T, et al. Ultrasonographically and anatomopathologically detectable node metastasis in the lateral compartment as indicators of worse relapse-free survival in patients with papillary thyroid carcinoma. World J Surg 2005;29:917–920

    Article  PubMed  Google Scholar 

  13. Ito Y, Tomoda C, Uruno T, et al. Clinical significance of metastasis to the central compartment from papillary microcarcinoma of the thyroid. World J Surg 2005;30:91–99

    Article  Google Scholar 

  14. General Rules for the Description of Thyroid Cancer, 6th edition. Kanehara Publishers, Tokyo, 2005

  15. Gimm O, Rath FW, Dralle H. Pattern of lymph node metastasis in papillary thyroid carcinoma. Br J Surg 1998;85:252–254

    Article  PubMed  CAS  Google Scholar 

  16. Uruno T, Miyauchi A, Shimizu K, et al. Usefulness of thyroglobulin measurement in fine-needle aspiration biopsy specimens for diagnosing cervical lymph node metastasis in patients with papillary thyroid cancer. World J Surg 2005;29:493–485

    Google Scholar 

  17. Maechens A, Holzhausen HJ, Dralle H. Skip metastasis in thyroid cancer leaping the central lymph node compartment. Arch Surg 2004;139:43–45

    Article  Google Scholar 

  18. Ito Y, Tomoda C, Uruno T, et al. Preoperative ultrasonographic examination for lymph node metastasis is useful when designing lymph node dissection for papillary microcarcinoma. World J Surgery 2004;28:498–501

    Article  Google Scholar 

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Authors and Affiliations

  1. Kuma Hospital, 8-2-35, Shimoyamate-Dori, Chuo-ku, Kobe City, 650-0011 , Japan

    Yasuhiro Ito MD, UVT, Tomoo Jikuzono MD, Takuya Higashiyama MD, Shuji Asahi MD, Chisato Tomoda MD, Yuuki Takamura MD, Akihiro Miya MD, Kaoru Kobayashi MD, Fumio Matsuzuka MD, Kanji Kuma MD & Akira Miyauchi MD

  2. Department of Surgery, Kuma Hospital, 8-2-35, Shimoyamate-Dori, Chuo-ku, Kobe City, 650-0011 , Japan

    Yasuhiro Ito MD, UVT

Authors
  1. Yasuhiro Ito MD, UVT
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  2. Tomoo Jikuzono MD
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  3. Takuya Higashiyama MD
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  4. Shuji Asahi MD
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  5. Chisato Tomoda MD
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  6. Yuuki Takamura MD
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  7. Akihiro Miya MD
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  8. Kaoru Kobayashi MD
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  9. Fumio Matsuzuka MD
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  10. Kanji Kuma MD
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  11. Akira Miyauchi MD
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Corresponding author

Correspondence to Yasuhiro Ito MD, UVT.

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Ito, Y., Jikuzono, T., Higashiyama, T. et al. Clinical Significance of Lymph Node Metastasis of Thyroid Papillary Carcinoma Located in One Lobe. World J. Surg. 30, 1821–1828 (2006). https://doi.org/10.1007/s00268-006-0211-5

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  • DOI: https://doi.org/10.1007/s00268-006-0211-5

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