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DRD2/DARPP-32 Expression Correlates with Lymph Node Metastasis and Tumor Progression in Patients with Esophageal Squamous Cell Carcinoma

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Abstract

Background

Dopamine receptors (DRs) are members of seven transmembrane domain trimeric guanosine 5’-triphosphate (GTP)-binding protein-coupled receptor family. Through dopamine receptor activation, dopamine plays a significant role in regulating gene expression, such as induced tumor cell migration.

Materials and Methods

We investigated DRD1 and DRD2 expressions in patients with esophageal squamous cell carcinoma (ESCC) for immunohistochemistry and analyzed differences between DRD1, DRD2, and DARPP-32 expressions of clinicopathological features in 122 patients with ESCC.

Results

DRD1 immunostaining correlated with the pathologic grade (P = 0.0127), and DRD2 immunostaining correlated with the pathologic stage (P = 0.0432) and pN classification (P = 0.0112). A significant correlation was found between DRD1 and DRD2 expression (P = 0.0292). However, no correlation was observed between DRD1/DRD2 expression and DARPP-32 expression (P = 0.4555 and 0.4774, respectively). No correlation was observed between the DRD1/DRD2 expression and patient prognosis. To find the cooperative role between DRD1, DRD2, and DARPP-32 expressions, patients were classified into the different groups. In the DRD2/DARPP-32 combination, the (+/−) group was significantly correlated with pathologic stage (P = 0.0006), lymph node metastasis (P = 0.0001), pT (P = 0.0287), and tumor size (P = 0.0202). Moreover, patients with this combination showed a lower survival rate compared with the other three groups (P = 0.0287).

Conclusions

We conclude that DRD2/DARPP-32 expression is associated with tumor progression and that DRD2/DARPP-32 expressions may help predict prognosis in patients with ESCC.

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Acknowledgements

We appreciate the contributions of Mr. Hiraku Shida and Ms. Rika Osanai for their technical support in immunohistochemistry and the many physicians who cared for patients at the affiliated hospitals of Surgical Oncology.

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Authors and Affiliations

  1. Department of Surgical Oncology, Division of Cancer Medicine, Hokkaido University Graduate School of Medicine, N15W7, Kita-ku, Sapporo, Hokkaido, 060-8638, Japan

    Li Li MD, Masaki Miyamoto MD, Yuma Ebihara MD, Seiji Mega MD, Ryo Takahashi MD, Ryunosuke Hase MD, Hiroyuki Kaneko MD, Masatoshi Kadoya MD, Toshiaki Shichinohe MD, Satoshi Hirano MD & Satoshi Kondo MD

  2. Department of Pathology, Hokkaido University Hospital, N14W5, Kita-ku, Sapporo, Hokkaido, 060-8648, Japan

    Tomoo Itoh MD

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  1. Li Li MD
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Correspondence to Li Li MD.

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Li, L., Miyamoto, M., Ebihara, Y. et al. DRD2/DARPP-32 Expression Correlates with Lymph Node Metastasis and Tumor Progression in Patients with Esophageal Squamous Cell Carcinoma. World J. Surg. 30, 1672–1679 (2006). https://doi.org/10.1007/s00268-006-0035-3

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