Abstract
Background
Benign peritoneal cystic mesothelioma (BPCM) is a rare tumor of unknown origin, most frequently encountered in women of reproductive age. Etiology is unknown; definitions and terminology are confusing, and preoperative diagnosis is difficult. Several differential diagnoses must be considered.
Methods
Based on our own clinical experience and a review of the relevant literature, we address clinical challenges and controversies of importance.
Results
Current literature on BPCM is mostly based on small case reports. Complete surgical resection is recommended if possible. Nevertheless, recurrent disease is not uncommon. Clinical positive effects of various adjuvant medical treatments remain to be shown.
Conclusions
Lack of consistent definitions, various treatment approaches, and mostly short follow-up times make it difficult to draw any firm conclusions from published reports. The natural history of this rare disease is less than well clarified. When possible, in an individual patient, surgical resection with curative intent seems to be the treatment of choice.
Similar content being viewed by others
References
Sawh RN, Malpica A, Deavers MT, et al. Benign cystic mesothelioma of the peritoneum: a clinicopathologic study of 17 cases and immunohistochemical analysis of estrogen and progesterone receptor status. Hum Pathol 2003;34:369–374
Daya D, McCaughey WT. Pathology of the peritoneum: a review of selected topics. Semin Diagn Pathol 1991;8:277–289
Ross MJ, Welch WR, Scully RE. Multilocular peritoneal inclusion cysts (so-called cystic mesotheliomas). Cancer 1989;64:1336–1346
Rosai J. Surgical Pathology, 9th edition, Edinburgh, London, New York, Oxford, Philadelphia, St Louis, Toronto, Mosby, 2004
Hejmadi R, Ganesan R, Kamal N. Malignant transformation of a well-differentiated peritoneal papillary mesothelioma. Acta Cytol 2003;47:517–518
Gonzalez-Moreno S, Yan H, Alcorn KW, et al. Malignant transformation of “benign” cystic mesothelioma of the peritoneum. J Surg Oncol 2002;79:243–251
Hutchinson R, Sokhi GS. Multicystic peritoneal mesothelioma: not a benign condition. Eur J Surg 1992;158:451–453
Iversen OH, Hovig T, Brandtzaeg P. Peritoneal, benign, cystic mesothelioma with free-floating cysts, re-examined by new methods. A case report. Acta Pathol Microbiol Immunol Scand 1988;96:123–127
Moriwaki Y, Kobayashi S, Harada H, et al. Cystic mesothelioma of the peritoneum. J Gastroenterol 1996;31:868–874
O’Neil JD, Ros PR, Storm BL, et al. Cystic mesothelioma of the peritoneum. Radiology 1989;170:333–337
De Perrot M, Brundler M, Totsch M, et al. Mesenteric cysts. Toward less confusion? Dig Surg 2000;17:323–328
Kjellevold K, Nesland JM, Holm R, et al. Multicystic peritoneal mesothelioma. Pathol Res Pract 1986;181:767–773
Sethna K, Mohamed F, Marchettini P, et al. Peritoneal cystic mesothelioma: a case series. Tumori 2003;89:31–35
Van Ruth S, Bronkhorst MW, van Coevorden F, et al. Peritoneal benign cystic mesothelioma: a case report and review of the literature. Eur J Surg Oncol 2002;28:192–195
Katsube Y, Mukai K, Silverberg SG. Cystic mesothelioma of the peritoneum: a report of five cases, review of the literature. Cancer 1982;50:1615–1622
Hafner M, Novacek G, Herbst F, et al. Giant benign cystic mesothelioma: a case report and review of literature. Eur J Gastroenterol Hepatol 2002;14:77–80
Iwasaki J, Yu TJ, Tamaru J, et al. A cystic adenomatoid tumor of the uterus simulating lymphangioma grossly. Acta Pathol Jpn 1985;35:989–993
Quigley JC, Hart WR. Adenomatoid tumors of the uterus. Am J Clin Pathol 1981;76:627–635
Asensio JA, Goldblatt P, Thomford NR. Primary malignant peritoneal mesothelioma. A report of seven cases, a review of the literature. Arch Surg 1990;125:1477–1481
Jones DE, Silver D. Peritoneal mesotheliomas. Surgery 1979;86:556–560
Antman KH. Clinical presentation, natural history of benign and malignant mesothelioma. Semin Oncol 1981;8:313–320
Mennemeyer R, Smith M. Multicystic, peritoneal mesothelioma: a report with electron microscopy of a case mimicking intra-abdominal cystic hygroma (lymphangioma). Cancer 1979;44:692–698
Ulvestad B, Kjaerheim K, Martinsen JI, et al. Cancer incidence among members of the Norwegian trade union of insulation workers. J Occup Environ Med 2004;46:84–89
De Toma G, Nicolanti V, Plocco M, et al. Cystic peritoneal mesothelioma: report of a case. Surg Today 2000;30:98–100
Datta RV, Paty PB. Cystic mesothelioma of the peritoneum. Eur J Surg Oncol 1997;23:461–462
Carpenter HA, Lancaster JR, Lee RA. Multilocular cysts of the peritoneum. Mayo Clin Proc 1982;57:634–638
Burrig KF, Pfitzer P, Hort W. Well-differentiated papillary mesothelioma of the peritoneum: a borderline mesothelioma. Report of two cases, review of literature. Virchows Arch A Pathol Anat Histopathol 1990;417:443–447
Riddell RH, Goodman MJ, Moossa AR. Peritoneal malignant mesothelioma in a patient with recurrent peritonitis. Cancer 1981;48:134–139
Kumar D, Dhar A, Jain R, et al. Benign cystic peritoneal mesothelioma in a man. Indian J Gastroenterol 1998;17:156–157
Ozgen A, Akata D, Akhan O, et al. Giant benign cystic peritoneal mesothelioma: US, CT, and MRI findings. Abdom Imaging 1998;23:502–504
Moore JH Jr, Crum CP, Chandler JG, et al. Benign cystic mesothelioma. Cancer 1980;45:2395–2399
Hasan AK, Sinclair DJ. Case report: calcification in benign cystic peritoneal mesothelioma. Clin Radiol 1993;48:66–67
Takenouchi Y, Oda K, Takahara O, et al. Report of a case of benign cystic mesothelioma. Am J Gastroenterol 1995;90:1165–1167
Bhandarkar DS, Smith VJ, Evans DA, et al. Benign cystic peritoneal mesothelioma. J Clin Pathol 1993;46:867–868
Tao LC. Aspiration biopsy cytology of mesothelioma. Diagn Cytopathol 1989;5:14–21
Usha Kiran TS, Agboola A, Davies R, et al. Benign cystic mesothelioma: a diagnostic dilemma. Aust N Z J Obstet Gynaecol 2002;42:552–554
Raafat F, Egan M. Benign cystic mesothelioma of the peritoneum: immunohistochemical, ultrastructural features in a child. Pediatr Pathol 1988;8:321–329
Friedman MT, Gentile P, Tarectecan A, et al. Malignant mesothelioma: immunohistochemistry and DNA ploidy analysis as methods to differentiate mesothelioma from benign reactive mesothelial cell proliferation and adenocarcinoma in pleural and peritoneal effusions. Arch Pathol Lab Med 1996;120:959–966
Vara-Thorbeck C, Toscano-Mendez R. Peritoneal cystic mesothelioma. Surg Endosc 2002;16:220
Rosai J, Dehner LP. Nodular mesothelial hyperplasia in hernia sacs: a benign reactive condition simulating a neoplastic process. Cancer 1975;35:165–175
Tzanakakis G, McCully KS, Vezeridis MP. Benign papillary mesothelioma of the peritoneum: a consideration in the differential diagnosis of peritoneal implants. South Med J 1989;82:1579–1580
Ricci F, Borzellino G, Ghimenton C, et al. Benign cystic mesothelioma in a male patient: surgical treatment by the laparoscopic route. Surg Laparosc Endosc 1995;5:157–160
Meister T, Birkfellner T, Poremba C, et al. Papillary mesothelioma of the peritoneum in the absence of asbestos exposure. Z Gastroenterol 2003;41:329–332
Adolph AJ, Smith TE, Adolph J Benign multicystic mesothelioma: a case report. J Obstet Gynaecol Can 2002;24:246–247
Hanukoglu A, Gewurtz G, Zaidel L, et al. Benign cystic mesothelioma of the peritoneum: the occurrence of an adult entity in a child. Med Pediatr Oncol 1992;20:169–171
Yan TD, Haveric N, Carmignani CP, et al. Abdominal computed tomography scans in the selection of patients with malignant peritoneal mesothelioma for comprehensive treatment with cytoreductive surgery and perioperative intraperitoneal chemotherapy. Cancer 2005;103:839–849
Author information
Authors and Affiliations
Corresponding author
Rights and permissions
About this article
Cite this article
Søreide, J.A., Søreide, K., Körner, H. et al. Benign Peritoneal Cystic Mesothelioma. World J. Surg. 30, 560–566 (2006). https://doi.org/10.1007/s00268-005-0639-z
Published:
Issue Date:
DOI: https://doi.org/10.1007/s00268-005-0639-z