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Roles of Neuropilins in Neuronal Development, Angiogenesis, and Cancers

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Abstract

Neuropilin-1 (NRP1) and neuropilin-2 (NRP2) are transmembrane glycoproteins that have been characterized as receptors for both semaphorins for neuronal guidance and vascular endothelial growth factor (VEGF) for angiogenesis. Biologic properties of NRPs have been linked to their unique domain structures. However, molecular interaction among NRPs, VEGF, and VEGF receptors is still not clear. Although several types of cancer cells can express NRPs, the role of NRPs in tumor pathogenesis is largely unknown. Thus, future investigations should include determining the effects and mechanisms of NRPs on proliferation, apoptosis, and migration of neuronal , endothelial, and cancer cells. Study of protein-protein interaction, signal transduction pathways, and NRP-mediated gene expression is particularly important to understand NRPs functions, which may have significant clinical applications in the treatment of neurological disorders, cardiovascular diseases, and certain cancers.

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Acknowledgment

This work was supported by National Institutes of Health Grants R01 HL61943 (C.C), R01 HL60135 (C.C), R01 HL65916 (C.C.), Methodist 39935 (M.L.), R01 HL72716 (C.C.), K08 CA85822 (W.F.), R13 CA101889 (F.C.B.), R21 AI 49116 (Q.Y.), and R01 DE015543 (Q.Y.).

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  1. Molecular Surgeon Research Center, Michael E. DeBakey Department of Surgery, Baylor College of Medicine and the Methodist Hospital, One Baylor Plaza, Mail Stop: NAB-2010, Houston, Texas, 77030, USA

    Changyi Chen M.D., Ph.D., Min Li Ph.D., Hong Chai M.D., Ph.D., Hui Yang M.D., Ph.D., William E. Fisher M.D. & Qizhi Yao M.D., Ph.D.

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  1. Changyi Chen M.D., Ph.D.
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Correspondence to Changyi Chen M.D., Ph.D..

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Chen, C., Li, M., Chai, H. et al. Roles of Neuropilins in Neuronal Development, Angiogenesis, and Cancers. World J. Surg. 29, 271–275 (2005). https://doi.org/10.1007/s00268-004-7818-1

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